Multidrug resistant typhoid fever: therapeutic considerations.

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dc.contributor.authorMishra, Sen_US
dc.contributor.authorPatwari, A Ken_US
dc.contributor.authorAnand, V Ken_US
dc.contributor.authorPillai, P Ken_US
dc.contributor.authorAneja, Sen_US
dc.contributor.authorChandra, Jen_US
dc.contributor.authorSharma, Den_US
dc.date.accessioned1992-04-01en_US
dc.date.accessioned2009-05-27T06:00:50Z
dc.date.available1992-04-01en_US
dc.date.available2009-05-27T06:00:50Z
dc.date.issued1992-04-01en_US
dc.description.abstractForty six blood culture positive cases were studied during the current outbreak of multidrug resistant typhoid fever (MRTF). The present outbreak was caused by E1 phage type and organisms were resistant to all commonly used drugs for the treatment of typhoid fever, viz., chloramphenicol (78%), co-trimoxazole (76%) and ampicillin (68%). Treatment failures with chloramphenicol (45.5%) corroborated well with in vitro resistance. No treatment failure was seen with chloramphenicol and ceftriaxone, when these drugs were used in cases infected with sensitive strains. Among the alternative drugs used in cases with in vitro sensitivity, successful clinical response was seen with ceftriaxone (4/4) and cefotaxime (8/9) as compared to cephalexin (3/5) or a combination of cephalexin and furazolidone (9/12).en_US
dc.description.affiliationDepartment of Pediatrics, Lady Hardinge Medical College, New Delhi.en_US
dc.identifier.citationMishra S, Patwari AK, Anand VK, Pillai PK, Aneja S, Chandra J, Sharma D. Multidrug resistant typhoid fever: therapeutic considerations. Indian Pediatrics. 1992 Apr; 29(4): 443-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/14448
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAmpicillin Resistance --physiologyen_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshChilden_US
dc.subject.meshChloramphenicol Resistance --physiologyen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshDrug Resistance, Microbial --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshSalmonella Phages --drug effectsen_US
dc.subject.meshSalmonella typhi --drug effectsen_US
dc.subject.meshTetracycline Resistance --physiologyen_US
dc.subject.meshTrimethoprim Resistance --physiologyen_US
dc.subject.meshTrimethoprim-Sulfamethoxazole Combination --pharmacologyen_US
dc.subject.meshTyphoid Fever --drug therapyen_US
dc.subject.meshUrban Populationen_US
dc.titleMultidrug resistant typhoid fever: therapeutic considerations.en_US
dc.typeComparative Studyen_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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