The current status of cholera vaccine development and experience with cholera vaccine trials in volunteers.

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dc.contributor.authorLevine, M Men_US
dc.contributor.authorKaper, J Ben_US
dc.contributor.authorHerrington, Den_US
dc.contributor.authorLosonsky, Gen_US
dc.contributor.authorTacket, Cen_US
dc.contributor.authorTall, Ben_US
dc.date.accessioned2009-05-27T15:30:22Z
dc.date.available2009-05-27T15:30:22Z
dc.date.issued1988-09-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractIn recent years notable advances have been made in the development of improved vaccines to prevent cholera. These new vaccines are administered orally to maximally stimulate intestinal secretory immunity. Killed vibrios, given in conjunction with purified B subunit or administered alone, in three spaced doses, caused no adverse reactions and have conferred significant protection in volunteer challenge studies and in field trials. Two attenuated mutants of V. cholerae, prepared by recombinant DNA techniques, CVD 103 and CVD 103-HgR are well-tolerated and elicit prominent immune responses and protective immunity after ingestion of a single oral dose. Other modern approaches being pursued include the development of auxotrophic strains and of modifying attenuated S. typhi strain Ty21a to express V. cholerae Inaba and Ogawa LPS antigens.en_US
dc.description.affiliationDepartment of Medicine, University of Maryland School of Medicine, Baltimore 21201.en_US
dc.identifier.citationLevine MM, Kaper JB, Herrington D, Losonsky G, Tacket C, Tall B. The current status of cholera vaccine development and experience with cholera vaccine trials in volunteers. The Southeast Asian Journal of Tropical Medicine and Public Health. 1988 Sep; 19(3): 401-15en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32950
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshCholera Vaccines --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshIntestines --immunologyen_US
dc.subject.meshSecretory Componenten_US
dc.subject.meshVaccines, Attenuated --isolation & purificationen_US
dc.subject.meshVibrio cholerae --immunologyen_US
dc.titleThe current status of cholera vaccine development and experience with cholera vaccine trials in volunteers.en_US
dc.typeJournal Articleen_US
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