HLA antigen pattern of Kashmiri patients with rheumatic heart disease.

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dc.contributor.authorBhat, M Sen_US
dc.contributor.authorWani, B Aen_US
dc.contributor.authorKoul, P Aen_US
dc.contributor.authorBisati, S Den_US
dc.contributor.authorKhan, M Aen_US
dc.contributor.authorShah, S Uen_US
dc.date.accessioned1997-06-01en_US
dc.date.accessioned2009-05-27T07:48:47Z
dc.date.available1997-06-01en_US
dc.date.available2009-05-27T07:48:47Z
dc.date.issued1997-06-01en_US
dc.description.abstractThe distribution of HLA class-I (A, B and C), and class II (DR and DQ) antigens was studied in 50 randomly selected Kashmiri Muslim patients with established rheumatic heart disease and compared with that of 50 controls of similar ethnicity. A significant increase in the frequency of HLA-DR4 (P < 0.005, RR 3.27) and a significant decrease in the frequency of HLA-B5 (P < 0.001, RR 0.19) were found in the patient group. Though HLA-DQ3 showed a significant increase (P < 0.005, RR 2.52) and HLA-DR7 a significant decrease (P < 0.05, RR 0.42) in the patient group, the corrected P value was not significant. The findings suggest that susceptibility to RHD in the studied population is HLA-related, with HLA-DR4 influencing its occurrence and HLA-B5 conferring protection against the same.en_US
dc.description.affiliationDepartment of Cardiology, Institute of Medical Sciences, Srinagar.en_US
dc.identifier.citationBhat MS, Wani BA, Koul PA, Bisati SD, Khan MA, Shah SU. HLA antigen pattern of Kashmiri patients with rheumatic heart disease. Indian Journal of Medical Research. 1997 Jun; 105(): 271-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/22166
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHLA Antigens --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshIslamen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRheumatic Heart Disease --immunologyen_US
dc.titleHLA antigen pattern of Kashmiri patients with rheumatic heart disease.en_US
dc.typeJournal Articleen_US
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