A study of intracoronary thrombolytic agents in high thrombus burden lesions during primary PCI

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dc.contributor.authorSarma, Venkata RS. Subrahmanyaen_US
dc.contributor.authorGopalakrishna, K.en_US
dc.contributor.authorRao, K. Purnachandraen_US
dc.contributor.authorSomasekahr, G.en_US
dc.contributor.authorChowdary, P.S.S.en_US
dc.contributor.authorRaghuram, P.en_US
dc.contributor.authorDasarath, B.en_US
dc.contributor.authorReddy, Manoharen_US
dc.contributor.authorRamkishoreen_US
dc.contributor.authorVeeramachineni, Rajien_US
dc.contributor.authorSasidhar, Y.en_US
dc.contributor.authorPrasad, M.en_US
dc.date.accessioned2025-08-13T11:15:21Z
dc.date.available2025-08-13T11:15:21Z
dc.date.issued2025-06
dc.description.abstractObjectives: High thrombus burden during Primary Percutaneous Coronary Intervention begets poor outcomes; there are several lacunas in the management of those patients.- The purpose of this study is to analyse the long- term outcomes of patients undergoing primary percutaneous coronary intervention with high thrombus burden, treated with intracoronary thrombolysis as an adjunctive therapy. Methods: In this prospective observational study, 108 consecutive primary percutaneous coronary intervention patients with high thrombus burden were stratified into two groups basing on whether they received intra- coronary thrombolytic agent before stent implantation. The primary outcome is Net Adverse Clinical Events. Secondary outcomes include Major Adverse Cardiac Events, and all other individual components of the Net Adverse Clinical Events when analysed separately. Results: The primary outcome events occurred in 21 patients (26 %) in the Primary stent group (n = 80), whereas it occurred in 2 patients (6 %) in the primary intra-coronary thrombolysis group (n = 28), this study shows that there is no difference in primary endpoints in both groups (26 % Vs 7 %, p-value – .042, Hazard ratio - 2.56; 95 % CI - .76–8.57), however Kaplan–Meier event-free survival curves show that both the curves are well separated apart even at the end of the one year of follow – up. Conclusion: There is no difference in the primary outcome events in both groups, however there was a consistent increase in events in the primary stent group over the one-year follow-up period. These findings suggest the need for a larger randomized clinical trial to confirm and further elucidate these results.en_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsCardiology Department, Aayush Hospitals, Vijayawada, Andhra Pradesh, Indiaen_US
dc.identifier.citationSarma Venkata RS. Subrahmanya, Gopalakrishna K., Rao K. Purnachandra, Somasekahr G., Chowdary P.S.S., Raghuram P., Dasarath B., Reddy Manohar, Ramkishore, Veeramachineni Raji, Sasidhar Y., Prasad M.. A study of intracoronary thrombolytic agents in high thrombus burden lesions during primary PCI. Indian Heart Journal. 2025 Jun; 77(3): 193-198en_US
dc.identifier.issn0019-4832
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253339
dc.languageenen_US
dc.publisherElsevieren_US
dc.relation.issuenumber3en_US
dc.relation.volume77en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2025.01.008en_US
dc.subjectPPCIen_US
dc.subjectPrimary percutaneous coronary agentsen_US
dc.subjectSTEMIen_US
dc.subjectST-Segment elevation myocardial infarctionen_US
dc.subjectNACEen_US
dc.subjectNet adverse clinical eventsen_US
dc.subjectSVDen_US
dc.subjectSingle vessel diseaseen_US
dc.subjectDVDen_US
dc.subjectDouble vessel diseaseen_US
dc.titleA study of intracoronary thrombolytic agents in high thrombus burden lesions during primary PCIen_US
dc.typeJournal Articleen_US
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