Epidemiology & management of persistent diarrhoea in children of developing countries.

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dc.contributor.authorBhan, M Ken_US
dc.contributor.authorBhandari, Nen_US
dc.contributor.authorBhatnagar, Sen_US
dc.contributor.authorBahl, Ren_US
dc.date.accessioned1996-07-01en_US
dc.date.accessioned2009-05-27T07:30:20Z
dc.date.available1996-07-01en_US
dc.date.available2009-05-27T07:30:20Z
dc.date.issued1996-07-01en_US
dc.description75 references.en_US
dc.description.abstractDiarrhoea that begins acutely but lasts longer than two weeks is defined to be persistent. Revised estimates in developing countries including India showed that acute diarrhoea accounts for 35 per cent, dysentery 20 per cent and non-dysenteric persistent diarrhoea (PD) for 45 per cent of total diarrhoeal deaths. PD also often changes marginal malnutrition to more severe forms. Factors that increase the risk of acute diarrhoea becoming persistent have been identified in India and other developing countries. These include antecedent malnutrition, micronutrient deficiency particularly for zinc and vitamin A, transient impairment in cell mediated immunity, infection with entero aggregative Escherichia coli and cryptosporidium, sequential infection with different pathogens and lack of exclusive breast feeding during the initial four months of life particularly use of bovine milk. Several issues regarding the management of persistent diarrhoea in hospitalized children in India have been resolved. Diets providing modest amounts of milk mixed with cereals are well tolerated. In those who fail on such diets providing carbohydrate as a mixture of cereals and glucose or sucrose hasten recovery. The role of antimicrobial agents and individual micronutrients in PD is currently being investigated. A management algorithm appropriate for India and other developing countries has been developed and found to substantially reduce case fatality in hospital settings to about 2-3 per cent. Recent epidemiological and clinical research related to persistent diarrhoea is also reviewed.en_US
dc.description.affiliationICMR Advance Centre for Diarrhoeal Disease Research, Department of Pediatrics All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationBhan MK, Bhandari N, Bhatnagar S, Bahl R. Epidemiology & management of persistent diarrhoea in children of developing countries. Indian Journal of Medical Research. 1996 Jul; 104(): 103-14en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/20977
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCattleen_US
dc.subject.meshChilden_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshDiarrhea --epidemiologyen_US
dc.subject.meshDieten_US
dc.subject.meshHumansen_US
dc.subject.meshIntestines --microbiologyen_US
dc.subject.meshMilken_US
dc.subject.meshRehydration Solutions --therapeutic useen_US
dc.titleEpidemiology & management of persistent diarrhoea in children of developing countries.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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