Neurostimulation in Childhood Epilepsy

Simple item page
dc.contributor.authorGhosh, Soumyaen_US
dc.contributor.authorNagarajan, Lakshmien_US
dc.date.accessioned2025-08-13T09:09:41Z
dc.date.available2025-08-13T09:09:41Z
dc.date.issued2025-05
dc.description.abstractEpilepsy is a common and debilita?ng neurological disorder in children, and approximately a third of them have ongoing seizures despite adequate trial of an?seizure medica?ons. Neuros?mula?on approaches may be an op?on for those with drug resistant epilepsy. Several invasive and non-invasive devices have been trialled and found to be effec?ve in reducing seizure burden in drug resistant epilepsy. These techniques appear to be safe and well tolerated. We review the available evidence for the use of these devices, including vagus nerve s?mula?on, deep brain s?mula?on, responsive neuros?mula?on, chronic subthreshold cor?cal s?mula?on, transcranial magne?c s?mula?on and transcranial direct current s?mula?on. The results of trials are promising but there are fewer studies in children. Apart from vagus nerve s?mula?on, none of the other neuros?mula?on techniques are currently approved for use in children and their use is off -label or in clinical trials. Further well-designed trials are needed, especially in children, to iden?fy the most effec?ve neuros?mula?on op?ons and op?mal parameters for improvement of seizure burden and quality of life. Neuros?mula?on techniques are also being trialled for treatment of refractory status epilep?cus, but lack of robust evidence (mainly case studies or case series reports) makes it difficult to predict therapeu?c benefit at present.en_US
dc.identifier.affiliationsChildren’s Neuroscience Service, Dept of Neurology, Perth Children’s Hospital, Nedlands, WA 6009, Australia; Perron Institute for Neurological and Translational Science, University of Western Australia, Nedlands, WA 6009, Australiaen_US
dc.identifier.affiliationsChildren’s Neuroscience Service, Dept of Neurology, Perth Children’s Hospital, Nedlands, WA 6009, Australia; School of Medicine, University of Western Australia, Nedlands, WA 6009, Australia.en_US
dc.identifier.citationGhosh Soumya, Nagarajan Lakshmi. Neurostimulation in Childhood Epilepsy. Indian Pediatrics. 2025 May; 62(5): 378-385en_US
dc.identifier.issn0019-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/251343
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber5en_US
dc.relation.volume62en_US
dc.source.urihttps://indianpediatrics.net/may2025/378.pdfen_US
dc.subjectDeep brain stimulationen_US
dc.subjectDrug resistant epilepsyen_US
dc.subjectNon-invasive brain stimulationen_US
dc.subjectResponsive neurostimulationen_US
dc.subjectVagus nerve stimulationen_US
dc.titleNeurostimulation in Childhood Epilepsyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ip2025v62n5p378.pdf
Size:
109.09 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Pediatrics