Pandemic Influenza A (H1N1) 2009 in India: Duration of virus shedding in patients under antiviral treatment.

Simple item page
dc.contributor.authorGandhoke, I
dc.contributor.authorRawat, D S
dc.contributor.authorRai, A
dc.contributor.authorKhare, S
dc.contributor.authorIchhpujani, R L
dc.date.accessioned2012-12-11T08:20:40Z
dc.date.available2012-12-11T08:20:40Z
dc.date.issued2011-01
dc.description.abstractBackground: National Centre for Disease Control (NCDC), Delhi, is a national nodal centre for surveillance of pandemic Influenza A (H1N1) in India. The present study was undertaken to see the period of infectivity in positive cases undergoing antiviral therapy. Objective: To assess the duration of virus shedding by real-time polymerase chain reaction (real-time PCR) in some of the positive patients taking Oseltamivir treatment. Materials and Methods: Clinical samples (throat swabs, nasal swabs and nasopharyngeal swabs) collected by the clinicians from patients quarantined in government hospitals in different parts of India are being sent to the designated reference laboratory at Delhi for screening presence of pandemic Influenza virus. The samples are tested by Real-Time PCR using CDC recommended reagents and protocol for confirmation of the H1N1 novel influenza virus. In 150 of the positive cases, we requested the clinicians to send samples for 5 consecutive days after administration of antiviral therapy, to see the trend of therapy response on viral shedding. Samples for more than 5 days were received from patients till they showed no amplification for any of the three target genes (Influenza A, Swine Influenza A or Swine H1). Results and Conclusion: In 99.33% (149/150) cases, the influenza infection resolved within 10 days. Sixty-four percent (96/150) of the positive patients turned negative within 5 days of the start of antiviral treatment. Only one patient belonging to high risk group showed prolonged virus shedding (19 days).en_US
dc.identifier.citationGandhoke I, Rawat D S, Rai A, Khare S, Ichhpujani R L. Pandemic Influenza A (H1N1) 2009 in India: Duration of virus shedding in patients under antiviral treatment. Indian Journal of Medical Microbiology. 2011 Jan-Mar; 29(1): 37-41.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/143773
dc.language.isoenen_US
dc.source.urihttps://www.ijmm.org/article.asp?issn=0255-0857;year=2011;volume=29;issue=1;spage=37;epage=41;aulast=Gandhokeen_US
dc.subjectInfluenza pandemicen_US
dc.subjectOseltamiviren_US
dc.subjectreal-time polymerase chain reactionen_US
dc.subjectvirus sheddingen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAntiviral Agents --administration & dosage
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIndia
dc.subject.meshInfant
dc.subject.meshInfluenza A Virus, H1N1 Subtype --isolation & purification
dc.subject.meshInfluenza, Human --drug therapy
dc.subject.meshInfluenza, Human --virology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshOseltamivir --administration & dosage
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction --methods
dc.subject.meshTime Factors
dc.subject.meshVirology --methods
dc.subject.meshVirus Shedding
dc.subject.meshYoung Adult
dc.titlePandemic Influenza A (H1N1) 2009 in India: Duration of virus shedding in patients under antiviral treatment.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijmm2011v29n1p37.pdf
Size:
1.59 MB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Medical Microbiology