Epidural ropivacaine combined with fentanyl or in combination with clonidine in infraumblical surgeries: a comparative study.

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dc.contributor.authorSingh, Rakesh Bahadur
dc.contributor.authorSingh, Dheer
dc.contributor.authorMishra, Prashant K
dc.contributor.authorKumar, Manoj
dc.contributor.authorKumar, Virendra
dc.date.accessioned2015-11-30T07:12:42Z
dc.date.available2015-11-30T07:12:42Z
dc.date.issued2015-10
dc.description.abstractBackground: The addition of an adjuvant, like clonidine and fentanyl, in epidural blockade has enhanced the effectiveness of local anaesthetics as they not only help in intensifying and prolonging the blockade effect but also help in the reduction of the dose of local anaesthetics. Methods: Our study had 45 patients, all patients belonged to ASA grade-I or II, between 20 and 55 years of age requiring neuraxial blockade for lower abdominal surgeries. All the patients were randomly allocated into two groups. Group-I: Epidural ropivacaine 0.75% (14.5ml) + Fentanyl 50 μgm (1 ml) + 0.5 ml distilled water. Group-II: Epidural ropivacaine 0.75% (14.5ml) + Fentanyl 50 μgm (1 ml) + clonidine 50 μgm. Patients were monitored for sensory and motor blockade, hemodynamic parameters, rescue analgesia and adverse effects in perioperative period. Results: Highest level of sensory and motor blockade was found to be insignificant (p>0.05) in both the groups. Mean time for regression of sensory blockade to T10 was significantly longer (p<0.05) in group II as compared to group I. The duration of motor blockade was significantly (p<0.001) higher in patients of Group-II as compared to Group-I. The addition of clonidine to epidural Ropivacaine and fentanyl (Group-II) produces longer duration of analgesia as compared to Group-I. Haemodynamically the patients in both the groups behaved similarly. The patients, in whom epidural fentanyl was used, had slightly higher incidence of nausea, vomiting, dry mouth and pruritus. Conclusions: So this study re-established the fact, that the fentanyl and clonidine when added as adjuvant to epidural ropivacaine, significantly prolongs the analgesic duration without causing significant hemodynamic and respiratory changes.en_US
dc.identifier.citationSingh Rakesh Bahadur, Singh Dheer, Mishra Prashant K, Kumar Manoj, Kumar Virendra. Epidural ropivacaine combined with fentanyl or in combination with clonidine in infraumblical surgeries: a comparative study. International Journal of Research in Medical Sciences. 2015 Oct; 3(10): 2740-2744.en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/166587
dc.language.isoenen_US
dc.source.urihttps://www.msjonline.org/?mno=200014en_US
dc.subjectEpiduralen_US
dc.subjectRopivacaineen_US
dc.subjectFentanylen_US
dc.subjectClonidineen_US
dc.titleEpidural ropivacaine combined with fentanyl or in combination with clonidine in infraumblical surgeries: a comparative study.en_US
dc.typeArticleen_US
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