An Indian Expert Group Review of Acanthosis Nigricans with Recommendations for Early Detection and Timely Management

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dc.contributor.authorTyebkhan, Gulrezen_US
dc.contributor.authorVelaskar, Sangeetaen_US
dc.contributor.authorYadav, Preetaen_US
dc.contributor.authorPhiske, Meghanaen_US
dc.contributor.authorShah, Duruen_US
dc.date.accessioned2024-11-30T08:55:56Z
dc.date.available2024-11-30T08:55:56Z
dc.date.issued2024-06
dc.description.abstractIntroduction: Acanthosis nigricans (AN) is a visible cutaneous manifestation of several underlying systemic conditions, such as prediabetes, diabetes mellitus (DM), polycystic ovarian syndrome (PCOS), metabolic syndrome (MS), and malignancy. AN is commonly seen in obese individuals and is a proven skin marker of insulin resistance (IR). Its typical clinical presentation and location, especially on the nape of the neck, allows for easy visual identification. Obesity, IR, and other noncommunicable diseases (NCD) are on the rise in India, with many cases being undiagnosed or missed. Every sixth diabetic in the world is Indian. AN can thus play a vital role in screening, early identification, and reduction of morbidity, especially of IR-related disorders. Currently, there are no national or international multidisciplinary guidelines or recommendations for AN. Objective: To review published current literature and evidence on AN, its associations, and management. To recommend an approach to clinical identification of AN, associated/underlying disorders, investigations, and management, including lifestyle modifications. To sensitize and familiarize clinicians and healthcare workers across India with AN presentations. This will enable early detection of conditions such as IR, prediabetes, DM, PCOS, malignancy, etc., in practice and in the community. Materials and methods: The PCOS Society of India constituted a multispecialty Expert Working Group with representation from various national societies to review all published scientific evidence. Expert group meetings were conducted to provide recommendations. Conclusion: Acanthosis nigricans is a simple, non-invasive, cost-effective screening tool for early identification of IR. It is important to integrate and disseminate information and training on AN across medical specialties. The government of India has launched several National Health Programmes to help address the rising burden of NCD in the population. AN would provide a simple screening tool to pick up undiagnosed or missed cases.en_US
dc.identifier.affiliationsConsultant Dermatologist, Department of Dermatology, Saifee Hospital, Mumbai, Maharashtraen_US
dc.identifier.affiliationsFormer Director-Medical and R&D, Kaya Limiteden_US
dc.identifier.affiliationsMedical Director, Skin Health Clinic, Mahim; Consultant Dermatologist, Raheja Hospital and BARC Hospitalen_US
dc.identifier.affiliationsAssociate Professor, Department of Dermatology, Mahatma Gandhi Mission Institute of Health Sciencesen_US
dc.identifier.affiliationsConsultant Obstetrician and Gynaecologist, President PCOS Society of India, Department of Gynaecology and Obstetrics, Breach Candy Hospital Trust, Jaslok Hospital, Mumbai, Maharashtra, Indiaen_US
dc.identifier.citationTyebkhan Gulrez, Velaskar Sangeeta, Yadav Preeta, Phiske Meghana, Shah Duru. An Indian Expert Group Review of Acanthosis Nigricans with Recommendations for Early Detection and Timely Management. Journal of the Association of Physicians of India. 2024 Jun; 72(6): 74–84en_US
dc.identifier.issn0004-5772
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237455
dc.languageenen_US
dc.publisherJournal of Indian Medical Associationen_US
dc.relation.issuenumber6en_US
dc.relation.volume72en_US
dc.source.urihttps://doi.org/10.59556/japi.72.0569en_US
dc.titleAn Indian Expert Group Review of Acanthosis Nigricans with Recommendations for Early Detection and Timely Managementen_US
dc.typeJournal Articleen_US
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