Clinical profile, visual outcome and root cause analysis of post-operative cluster endophthalmitis due to Burkholderia cepacia complex

Simple item page
dc.contributor.authorDeb, Amit Kumaren_US
dc.contributor.authorChavan, Pratimaen_US
dc.contributor.authorKaliaperumal, Subashinien_US
dc.contributor.authorSistla, Sujathaen_US
dc.contributor.authorMadigubba, Harithaen_US
dc.contributor.authorSarkar, Sandipen_US
dc.contributor.authorNeena, Aswathien_US
dc.date.accessioned2023-08-25T06:31:34Z
dc.date.available2023-08-25T06:31:34Z
dc.date.issued2022-01
dc.description.abstractPurpose: To present varied clinical presentations, surveillance reports, and final visual outcomes of a rare outbreak of cluster endophthalmitis caused by gram?negative, opportunistic bacilli, Burkholderia cepacia complex (Bcc). Methods: Details of five patients who developed postoperative cluster endophthalmitis were collected. For each patient, an undiluted vitreous sample was collected during vitreous tap. Bacterial culture from the vitreous sample in each case had grown Bcc. Surveillance investigations for root cause analysis (RCA) were performed in the operating room (OR), admission, and day?care wards to localize the source. Results: Four patients had undergone phacoemulsification surgery, and one patient had undergone penetrating keratoplasty. Each patient received an initial dose of empiric intravitreal ceftazidime and vancomycin. The organism isolated in each case was sensitive to ceftazidime, cotrimoxazole, and meropenem and resistant to other antibiotics. Core vitrectomy was done after 48–60 hours in four patients along with intravitreal imipenem injection. One patient did not provide consent for core vitrectomy and subsequently developed phthisis bulbi. Three patients had subsequent recurrences. Two patients had a final BCVA of 20/60, two had BCVA better than 20/200, while one patient had no perception of light. None of the surveillance samples from the OR complex could isolate Burkholderia. Conclusion: Extensive OR surveillance should be done to identify the potential source of infection. However, the source may not be identifiable in few instances like in our case. Longer follow?up is recommended in cases of Bcc endophthalmitis due to the persistent nature of the infectionen_US
dc.identifier.affiliationsDepartment of Microbiology, Jawaharlal Institute Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.citationDeb Amit Kumar, Chavan Pratima, Kaliaperumal Subashini, Sistla Sujatha, Madigubba Haritha, Sarkar Sandip, Neena Aswathi. Clinical profile, visual outcome and root cause analysis of post-operative cluster endophthalmitis due to Burkholderia cepacia complex. Indian Journal of Ophthalmology. 2022 Jan; 70(1): 164-170en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224080
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber1en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1035_21en_US
dc.subjectBurkholderia cepacia complexen_US
dc.subjectcluster endophthalmitisen_US
dc.subjectpostoperative endophthalmitisen_US
dc.subjectroot cause analysisen_US
dc.titleClinical profile, visual outcome and root cause analysis of post-operative cluster endophthalmitis due to Burkholderia cepacia complexen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJO2022v70n1p164.pdf
Size:
2.95 MB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Ophthalmology