Clinical features and orbital anomalies in Fraser syndrome and a review of management options

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dc.contributor.authorDas, Deepsekharen_US
dc.contributor.authorModaboyina, Sujeethen_US
dc.contributor.authorRaj, Sandtonen_US
dc.contributor.authorAgrawal, Sahilen_US
dc.contributor.authorBajaj, Mandeep Singhen_US
dc.date.accessioned2023-08-25T06:33:45Z
dc.date.available2023-08-25T06:33:45Z
dc.date.issued2022-07
dc.description.abstractPurpose: Fraser syndrome is a rare congenital disorder comprising cryptophthalmos, syndactyly, and many times, urogenital anomalies. Herein, the authors aimed to study and report the clinical features and orbital anomalies in cases diagnosed with Fraser syndrome. Methods: The authors retrospectively evaluated the records of patients with Fraser syndrome who had presented to a tertiary eye care hospital in northern India in the last 2 years (from January 2019 to December 2020). The clinical features were studied, entered in MS Excel, and the data was evaluated. Results: Data of 15 patients with Fraser syndrome were found. Majority of the patients were males and presented in the pediatric age group. Bilateral involvement was more common, and the most common variant of cryptophthalmos was abortive. Complete and medial madarosis of the eyebrows was the most common periocular finding. Complete cryptophthalmos was associated with cystic globes, whereas abortive forms had superior symblepharon. Common systemic features included syndactyly, bifid nose, and urogenital anomaly. Conclusion: Fraser syndrome is an extremely rare developmental disorder; it encompasses a wide range of ocular, periocular, and orbital anomalies, along with multiple pre?existing systemic anomalies. The treating ophthalmologist should always be careful in examining these patientsen_US
dc.identifier.affiliationsDepartment of Oculoplasty and Orbital Tumor Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationDas Deepsekhar, Modaboyina Sujeeth, Raj Sandton, Agrawal Sahil, Bajaj Mandeep Singh. Clinical features and orbital anomalies in Fraser syndrome and a review of management options. Indian Journal of Ophthalmology. 2022 Jul; 70(7): 2559-2563en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224430
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber7en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_2627_21en_US
dc.subjectAbortive Cryptophthalmosen_US
dc.subjectcomplete cryptophthalmosen_US
dc.subjecteyelid developmental disorderen_US
dc.subjectFraser syndromeen_US
dc.subjectsyndactylyen_US
dc.titleClinical features and orbital anomalies in Fraser syndrome and a review of management optionsen_US
dc.typeJournal Articleen_US
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