Thyroid function in thalassaemia major.

Simple item page
dc.contributor.authorSenanayake, M Pen_US
dc.contributor.authorSuraweera, S Aen_US
dc.contributor.authorHubert, H Den_US
dc.date.accessioned2009-05-28T05:11:12Z
dc.date.available2009-05-28T05:11:12Z
dc.date.issued1999-12-15en_US
dc.descriptionThe Ceylon Medical Journal.en_US
dc.description.abstractINTRODUCTION: Short stature is common in thalassaemia major. Hypothyroidism resulting from haemosiderosis has been implicated, but this complication has not been investigated in Sri Lanka. OBJECTIVES: To estimate the thyroid hormone level of patients with thalassaemia major and correlate height with age, iron status and thyroid hormone level. SETTING: University Unit, Lady Ridgeway Hospital, Colombo. DESIGN: A cross-sectional comparative study. METHODS: 33 patients with thalassemia major (19 males) aged 2 years 6 months to 23 years were studied. 21 healthy age and sex matched subjects from the same neighbourhood as the patients served as controls. Anthropometric measurements, skeletal maturity, serum ferritin and thyroid hormone levels were estimated. RESULTS: The height centiles and height standard deviation scores (SDS) were significantly lower in the patient group. Skeletal maturation was delayed by more than 1 year in 69% of patients. Undernutrition was not seen. The height SDS showed significant reduction with age (r = -0.5, 95% confidence limit -0.72 to -0.18) and with elevated serum ferritin levels (r = -0.8, 95% confidence limit = -0.9 to 0.62). Serum ferritin levels were elevated in the entire patient group with 70% being heavily iron overloaded (serum ferritin > 7000 ng/ml). The thyroxine (T4) levels were within the normal range in all 33 patients. The TSH levels were normal in 32 patients. The patient too had a normal T4 level. The control group had TSH levels comparable with the patients. CONCLUSION: Hypothyroidism was not present in our iron overloaded thalassaemic patients. The thyroid hormone levels were similar in patients with mild and heavy iron overload. We conclude that routine surveillance for hypothyroidism is unnecessary in thalassaemia major. Other causes for delayed skeletal maturation and short stature need investigation.en_US
dc.identifier.citationSenanayake MP, Suraweera SA, Hubert HD. Thyroid function in thalassaemia major. The Ceylon Medical Journal. 1999 Dec; 44(4): 166-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/48072
dc.language.isoengen_US
dc.source.urihttps://www.infolanka.com/CMJhome/en_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Determination by Skeletonen_US
dc.subject.meshBody Heighten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFerritins --blooden_US
dc.subject.meshGrowth Disorders --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidism --blooden_US
dc.subject.meshIron Overload --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshThyrotropin --blooden_US
dc.subject.meshThyroxine --blooden_US
dc.subject.meshbeta-Thalassemia --blooden_US
dc.titleThyroid function in thalassaemia major.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Ceylon Medical Journal