Sonographic Evaluation of Carotid Intima-Media Thickness and Iron Status of Regular and First-Time Blood Donors in a Tertiary Hospital in South-West Nigeria

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dc.contributor.authorO. F., Okekeen_US
dc.contributor.authorA. A. O., Adeyomoyeen_US
dc.contributor.authorA. S., Akanmuen_US
dc.contributor.authorO. C., Nwanna-Otolehien_US
dc.contributor.authorG., Iyizobaen_US
dc.date.accessioned2025-05-09T06:23:04Z
dc.date.available2025-05-09T06:23:04Z
dc.date.issued2024-09
dc.description.abstractBackground: Regular blood donation which decreases blood iron levels may protect against cardiovascular diseases (CVD). This protection against atherosclerosis can be assessed by Carotid Intima-Media Thickness (CIMT) a biomarker for atherosclerosis. This study sought to determine and compare the mean and maximum CIMT, the serum level of iron and plaque prevalence among regular and first-time blood donors in Lagos University Teaching Hospital (LUTH), Lagos. Methods: A comparative, cross-sectional study involving 214 randomly-selected blood donors (107 regular and first-time blood donors each). Using a structured proforma, sociodemographic, anthropometric, radiological and laboratory data were collected from blood donors in the two groups. high frequency linear probe was used to assess CIMT, and presence of plaque in both extra-cranial carotid arteries. CIMT was the distance between the intima–blood interface and the adventitia–media junction and iron study included serum total iron, ferritin, transferrin and total iron binding capacity. Comparison between the study groups was done by Chi-square test and Student t-test/Mann-Whitney U-test for categorical and continuous variables respectively. Level of significance was set at p<0.05. Results: The mean and maximum CIMT of both carotid arteries in regular blood donors (mean right CIMT-0.49+/-0.11mm, maximum right CIMT-0.58+/-0.14mm, mean left CIMT-0.51+/-0.16mm, maximum left CIMT-0.60+/-0.27mm) were significantly(p<0.05) lower than those of the first-time blood donors(Mean right CIMT-0.79+/-0.17mm, maximum right CIMT-0.93+/-0.25mm, mean left CIMT-0.83+/-0.31mm, maximum left CIMT-0.96+/-0.27mm). Median serum iron(10.5µmol/L; IQR:8.8-13.5µmol/L), ferritin(30.50µg/ml; IQR:16.2-600µg/ml) and transferrin(2.1g/L;IQR:0.9-2.3g/L) in regular blood donors were significantly lower(p<0.05) than serum iron (16.1µmol/L; IQR:13.7-18.6µmol/L), ferritin(158.0µg/ml; IQR:115-365.2µg/ml) and transferrin(2.3g/L; IQR:2.1-2.4g/L) in first-time donors. Plaque prevalence was significantly higher (?2=5.81; p – 0.016) in first-time (11.2%) than regular (2.8%) donors. Conclusion: Regular blood donation significantly lower CIMT values, and iron parameters. Regular blood donation may offer protection against atherosclerosis.en_US
dc.identifier.affiliationsDepartment of Radiotherapy, Radiodiagnosis, Radiation Biology and Radiography, Lagos University Teaching Hospital, Idi Araba, Lagos, Nigeriaen_US
dc.identifier.affiliationsDepartment of Radiotherapy, Radiodiagnosis, Radiation Biology and Radiography, Lagos University Teaching Hospital, Idi Araba, Lagos, Nigeriaen_US
dc.identifier.affiliationsDepartment of Haematology and Blood Transfusion, Lagos University Teaching Hospital, Idi Araba, Lagos, Nigeriaen_US
dc.identifier.affiliationsDepartment of Radiotherapy, Radiodiagnosis, Radiation Biology and Radiography, Lagos University Teaching Hospital, Idi Araba, Lagos, Nigeriaen_US
dc.identifier.affiliationsDepartment of Radiodiagnosis, Lagos University Teaching Hospital, Idi Araba, Lagos, Nigeria.en_US
dc.identifier.citationO. F. Okeke, A. A. O. Adeyomoye, A. S. Akanmu, O. C. Nwanna-Otolehi, G Iyizoba. Sonographic Evaluation of Carotid Intima-Media Thickness and Iron Status of Regular and First-Time Blood Donors in a Tertiary Hospital in South-West Nigeria . International Blood Research & Reviews. 2024 Sep; 15(3): 7-21en_US
dc.identifier.issn2321-7219
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/242670
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber3en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.9734/ibrr/2024/v15i3340en_US
dc.subjectRegular blood donationen_US
dc.subjectserum ironen_US
dc.subjectserum ferritinen_US
dc.subjectcarotid intima-media thicknessen_US
dc.subjectatherosclerosisen_US
dc.titleSonographic Evaluation of Carotid Intima-Media Thickness and Iron Status of Regular and First-Time Blood Donors in a Tertiary Hospital in South-West Nigeriaen_US
dc.typeJournal Articleen_US
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