Pathogenesis of peptic ulcer disease and current trends in therapy.

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dc.contributor.authorDesai, J Ken_US
dc.contributor.authorGoyal, R Ken_US
dc.contributor.authorParmar, N Sen_US
dc.date.accessioned1997-01-01en_US
dc.date.accessioned2009-06-01T06:47:45Z
dc.date.available1997-01-01en_US
dc.date.available2009-06-01T06:47:45Z
dc.date.issued1997-01-01en_US
dc.description87 references.en_US
dc.description.abstractTraditionally drugs used in peptic ulcer have been directed mainly against a single luminal damaging agent i.e. hydrochloric acid and a plethora of drugs like antacids, anticholinergics, histamine H2-antagonists etc. have flooded the market. An increase in 'aggressive' factors like acid and pepsin is found only in a minority of peptic ulcer patients. These factors do not alter during or after spontaneous healing. It is well-known that the gastric mucosa can resist auto-digestion though it is exposed to numerous 'insults' like high concentration of hydrochloric acid, pepsin, reflux of bile, spicy food, microorganisms and at times alcohol and irritant drugs. It is thus evident that the integrity of the gastric mucosa is maintained by defense mechanisms against these 'aggressive' damaging factors. Recently, attention has been focused more on gastroduodenal defense mechanisms leading to the concept of 'Cytoprotection'. The old dictum "no acid--no ulcer" now extends to "if acid--why ulcer"? as a fundamental question. During last decade more information has poured in about the prevalence and changing pattern of the disease, the influence of environmental factors and speculation on the role of a recently characterized bacterial organism, Helicobacter pylori which colonizes in the gastric mucosa, particularly the antral region. This review briefly describes current knowledge about the pathogenesis of peptic ulcer disease and discusses strategies for its treatment.en_US
dc.description.affiliationDepartment of Pharmacology, L.M. College of Pharmacy, Navrangpura, Ahmedabad.en_US
dc.identifier.citationDesai JK, Goyal RK, Parmar NS. Pathogenesis of peptic ulcer disease and current trends in therapy. Indian Journal of Physiology and Pharmacology. 1997 Jan; 41(1): 3-15en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107661
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --therapeutic useen_US
dc.subject.meshDrug Therapy --trendsen_US
dc.subject.meshHelicobacter Infections --drug therapyen_US
dc.subject.meshHelicobacter pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshPeptic Ulcer --drug therapyen_US
dc.titlePathogenesis of peptic ulcer disease and current trends in therapy.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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