Epidemiology and Spectrum of lymphoma in a single tertiary care hospital of North India

Simple item page
dc.contributor.authorShukla, Anjuen_US
dc.contributor.authorSingh, Poonamen_US
dc.contributor.authorGupta, Surbhien_US
dc.contributor.authorJain, Priyankaen_US
dc.contributor.authorShukla, Anjikaen_US
dc.date.accessioned2023-07-14T07:51:28Z
dc.date.available2023-07-14T07:51:28Z
dc.date.issued2022-10
dc.description.abstractBackground: Non-Hodgkin抯 Lymphoma is a common hematological malignancy. Its incidence and distribution in India are slightly different from developed nations. The study was initiated to obtain the epidemiological, clinical and histopathological spectrum of lymphoma in a single tertiary care hospital of North India. Methods: 104 eligible consecutive cases of lymphoma were retrospectively analyzed from January 2016 to March 2020. Morphology and immunohistochemistry were performed and clinical details were captured from hospital information system. Cases were reclassified according to WHO classification of Tumors of Hematopoietic and Lymphoid Tissue 2017 and also clinically as nodal and extra nodal lymphomas and analyzed. Results: Among the included patients 14.4% patients are diagnosed as Hodgkin抯 lymphoma (HL) while 85.5% belonged to non-Hodgkin抯 lymphoma (NHL). Median age for NHL is 52.5 years. Male outnumbered females in both NHL and HL with ratio of 1.87 and 1.5. Majority of NHL are mature B-cell neoplasm (83.1%), while mature T-cell and NK cell neoplasm are less (14.6%). Most common subtype found is Diffuse large B-cell lymphoma (52.8%) followed by Primary diffuse large B cell lymphoma of CNS (15.7%). Primarily nodal Vs extranodal involvement is seen in 51.9% and 48% of cases. Most common extranodal site is CNS followed by GIT and spine. Conclusion: In the present study DLBL is the most common subtype seen in 52.8% of cases in concordance with other studies but the sticking difference here is low incidence of follicular lymphoma and CLL/SLL and a much higher incidence of Primary DLBCL of CNS. There is an Inherited selection bias because the cases are collected from single institution; however, causes and reasons should be more extensively investigated.en_US
dc.identifier.affiliationsPathologist, Department of Lab Medicine, Sahara Hospital, Lucknow, Indiaen_US
dc.identifier.affiliationsPathologist, Department of Lab Medicine, Sahara Hospital, Lucknow, Indiaen_US
dc.identifier.affiliationsPathologist, Department of Lab Medicine, Sahara Hospital, Lucknow, Indiaen_US
dc.identifier.affiliationsPathologist, Department of Lab Medicine, Sahara Hospital, Lucknow, Indiaen_US
dc.identifier.affiliationsStudent, Department of Biotechnology, Vellore Institute of Technology, Vellore, Indiaen_US
dc.identifier.citationShukla Anju, Singh Poonam, Gupta Surbhi, Jain Priyanka, Shukla Anjika. Epidemiology and Spectrum of lymphoma in a single tertiary care hospital of North India. SSR Institute of International Journal of Life Sciences. 2022 Oct; 8(5): 3075-3083en_US
dc.identifier.issn2581-8740
dc.identifier.issn2581-8732
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/218926
dc.languageenen_US
dc.publisherSociety for Scientific Researchen_US
dc.relation.issuenumber5en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.21276/SSR-IIJLS.2022.8.5.1en_US
dc.subjectExtranodalen_US
dc.subjectHodgkin抯en_US
dc.subjectLymphomaen_US
dc.subjectNon-Hodgkin抯en_US
dc.subjectNodalen_US
dc.titleEpidemiology and Spectrum of lymphoma in a single tertiary care hospital of North Indiaen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
SSRIIJLS2022v8n5p3075.pdf
Size:
1.33 MB
Format:
Adobe Portable Document Format
Download
Collections
SSR Institute of International Journal of Life Sciences