A randomized double-blind controlled study of nimodipine in acute cerebral ischemic stroke.

dc.contributor.authorNag, Den_US
dc.contributor.authorGarg, R Ken_US
dc.contributor.authorVarma, Men_US
dc.date.accessioned1998-10-30en_US
dc.date.accessioned2009-06-01T05:13:26Z
dc.date.available1998-10-30en_US
dc.date.available2009-06-01T05:13:26Z
dc.date.issued1998-10-30en_US
dc.description.abstractA randomized placebo controlled double-blind clinical trial of nimodipine was conducted in 31 patients of acute cerebral infarction. Nimodipine was administered in dosage of 120 mg/day for 28 days. Treatment was begun within 48 hours of ischemic stroke. Diagnosis was confirmed by computed tomographic (CT) scan. Similar number of patients (control) received placebo. Neurological assessment was done at the time of entry into the trial, and after 4 weeks, by using Mathew's scale. After four weeks of treatment with nimodipine or placebo, Mathew's scale score improved significantly (< 0.001) in both groups, but difference in mean score between two groups was insignificant (> 0.05). However, significant difference (< 0.05) was noted in relative change in neurological deficit (mean X-value) of two groups. The nimodipine group had higher value in scores on Mathew's scale. No adverse reaction, was observed in either group. The study suggests a beneficial a effect of nimodipine in acute cerebral ischaemia.en_US
dc.description.affiliationDepartment of Neurology, King George's Medical College, Lucknow.en_US
dc.identifier.citationNag D, Garg RK, Varma M. A randomized double-blind controlled study of nimodipine in acute cerebral ischemic stroke. Indian Journal of Physiology and Pharmacology. 1998 Oct; 42(4): 555-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106448
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBrain Ischemia --drug therapyen_US
dc.subject.meshCalcium Channel Blockers --therapeutic useen_US
dc.subject.meshCerebral Infarction --drug therapyen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeuropsychological Testsen_US
dc.subject.meshNimodipine --therapeutic useen_US
dc.titleA randomized double-blind controlled study of nimodipine in acute cerebral ischemic stroke.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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