Doxycycline in the treatment of rheumatoid arthritis--a pilot study.

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dc.contributor.authorSreekanth, V Ren_US
dc.contributor.authorHanda, Ren_US
dc.contributor.authorWali, J Pen_US
dc.contributor.authorAggarwal, Pen_US
dc.contributor.authorDwivedi, S Nen_US
dc.date.accessioned2000-08-29en_US
dc.date.accessioned2009-05-31T02:48:10Z
dc.date.available2000-08-29en_US
dc.date.available2009-05-31T02:48:10Z
dc.date.issued2000-08-29en_US
dc.description.abstractOBJECTIVE: To assess the efficacy and safety of doxycycline as a disease modifying anti-rheumatic drug (DMARD) in rheumatoid arthritis (RA) and compare it with methotrexate, a standard DMARD. MATERIAL AND METHODS: A single (assessor) blind prospective study with 15 patients of RA randomized to doxycycline and 14 to methotrexate. Baseline disease characteristics were similar in both groups. RESULTS: All disease activity measures studied viz. tender and swollen joint counts, physician and patient global assessment, visual analogue pain scale, health assessment questionnaire and ESR improved in both the treatment groups after six months of treatment. The difference between doxycycline and methotrexate was not statistically significant. No major side effects necessitating drug withdrawal were reported from either group. The side effects were few and mostly gastrointestinal. CONCLUSION: Doxycycline is a safe disease modifying drug in RA whose effect is sustained at six months. It compared favourably with methotrexate over a six month follow up.en_US
dc.description.affiliationDepartment of Medicine, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSreekanth VR, Handa R, Wali JP, Aggarwal P, Dwivedi SN. Doxycycline in the treatment of rheumatoid arthritis--a pilot study. Journal of the Association of Physicians of India. 2000 Aug; 48(8): 804-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/93355
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntirheumatic Agents --adverse effectsen_US
dc.subject.meshArthritis, Rheumatoid --drug therapyen_US
dc.subject.meshDoxycycline --adverse effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMethotrexate --adverse effectsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSingle-Blind Methoden_US
dc.subject.meshTreatment Outcomeen_US
dc.titleDoxycycline in the treatment of rheumatoid arthritis--a pilot study.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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