Effect of luteinizing hormone releasing hormone analogues on testosterone metabolism in vitro —A study with mature rat ventral prostates.
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Date
1988-06
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Abstract
The effects of two luteinizing hormone releasing hormone analogues (a superagonist
and an antagonist) on the conversion of testosterone to dihydrotestosterone in homogenates
prepared from adult rat ventral prostates were studied. At higher doses, the superagonist
showed a significant dose-dependent inhibition of the conversion of testosterone to
dihydrotestosterone. In comparison, the antagonist showed only a marginally inhibitory
trend. The implications of these observed effects vis-a-vis the use of the analogues in the
endocrine management of prostatic cancer have been discussed.
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Keywords
Prostate, LHRH analogues, testosterone metabolism, 5 α-reductase activity
Citation
Maitra A, Joseph R, Sheth A R, Sheth N A, Joseph J. Effect of luteinizing hormone releasing hormone analogues on testosterone metabolism in vitro —A study with mature rat ventral prostates. Journal of Biosciences. 1988 Jun; 13(2): 105-108.