Effects of acute administration of nifedipine on glomerular filtration rate and urinary excretion of sodium and uric acid in patients with mild-moderate essential hypertension.

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dc.contributor.authorRoychowdhury, Den_US
dc.contributor.authorPadhy, A Ken_US
dc.contributor.authorTiwari, S Cen_US
dc.contributor.authorGupta, Ken_US
dc.contributor.authorGopinath, P Gen_US
dc.contributor.authorMalhotra, K Ken_US
dc.date.accessioned1988-10-01en_US
dc.date.accessioned2009-06-01T05:29:54Z
dc.date.available1988-10-01en_US
dc.date.available2009-06-01T05:29:54Z
dc.date.issued1988-10-01en_US
dc.description.abstractA prospective study was conducted in 25 patients with essential hypertension to study the effects of sublingual administration of nifedipine on some renal functions. Glomerular filtration rate was estimated by radioisotope clearance techniques using Tc-99m diethylene triamine pentaacetic acid (DTPA). The change in urinary excretion of sodium and uric acid were also monitored. A basal estimation of these parameters was followed by repeat studies after lowering the blood pressure to normotensive levels by sublingual administration of nifedipine. It was observed that acute administration of nifedipine does not produce a significant change in the glomerular filtration rate, but causes marked and significant natriuresis and uricosuria.en_US
dc.description.affiliationDepartment of Nuclear Medicine, All-India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationRoychowdhury D, Padhy AK, Tiwari SC, Gupta K, Gopinath PG, Malhotra KK. Effects of acute administration of nifedipine on glomerular filtration rate and urinary excretion of sodium and uric acid in patients with mild-moderate essential hypertension. Indian Journal of Physiology and Pharmacology. 1988 Oct-Dec; 32(4): 278-84en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106659
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdministration, Sublingualen_US
dc.subject.meshAdulten_US
dc.subject.meshClinical Trials as Topicen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlomerular Filtration Rate --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNatriuresis --drug effectsen_US
dc.subject.meshNifedipine --administration & dosageen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSodium --urineen_US
dc.subject.meshUric Acid --urineen_US
dc.titleEffects of acute administration of nifedipine on glomerular filtration rate and urinary excretion of sodium and uric acid in patients with mild-moderate essential hypertension.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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