The antibiotics of choice for the treatment of melioidosis in Indian set up.
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Date
2016-07
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Abstract
Therapeutic options for the treatment of melioidosis caused by Burkholderia pseudomallei are limited due to the
inherent resistance conferred by this pathogen to various groups of antibiotics. Witnessing an increase in the number
of microbiological culture‑confirmed cases of melioidosis at our settings in the past few years, we undertook this
study to estimate the minimum inhibitory concentrations of clinical isolates of B. pseudomallei against the four
commonly employed antimicrobial agents in the patient management at our settings, namely, ceftazidime, meropenem,
trimethoprim‑sulfamethoxazole and doxycycline. All isolates were susceptible to the antibiotics tested, except for one
isolate which showed resistance to doxycycline (minimum inhibitory concentration [MIC]: 32 µg/ml). MIC50 and 90 for
all the four antibiotics were estimated. From this study, we conclude that the clinical isolates of B. pseudomallei from the
southern part of India are well susceptible to the commonly employed antimicrobial agents for therapy.
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Keywords
Burkholderia pseudomallei, melioidosis, minimum inhibitory concentration
Citation
Shaw T, Tellapragada C, Eshwara V K, Bhat H V, Mukhopadhyay C. The antibiotics of choice for the treatment of melioidosis in Indian set up. Indian Journal of Medical Microbiology. 2016 July-Sept; 34(3): 353-354.