Typhoid fever: narrowing therapeutic options in India.

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dc.contributor.authorCapoor, Malini Ren_US
dc.contributor.authorNair, Deepthien_US
dc.contributor.authorHasan, Azra Sen_US
dc.contributor.authorAggarwal, Pushpaen_US
dc.contributor.authorGupta, Ben_US
dc.date.accessioned2009-05-27T16:10:07Z
dc.date.available2009-05-27T16:10:07Z
dc.date.issued2006-11-06en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractTyphoid fever remains an important public health problem in India. One thousand four hundred fifty-eight blood cultures were screened, 178 grew out Salmonella enterica serovar Typhi. On agar dilution minimum inhibitory concentration (MIC) testing, 0.6% of the isolates were resistant to ciprofloxacin, 2% to cefotaxime and 1% to cefepime. Nalidixic acid resistance was observed in 51% isolates, of which 98.9% had decreased susceptibility (MIC > or = 0.125-4 microg/ml) to ciprofloxacin. One strain of nalidixic acid sensitive S. Typhi (NASST) also had a decreased MIC (0.125 microg/ml) to ciprofloxacin. Resistance to third and fourth generation cephalosporins is emerging in India and will gain significance in the coming decade. The molecular basis of resistance to cephalosporinsand ciprofloxacin resistance in NASST strains need to be further evaluated for S. Typhi.en_US
dc.description.affiliationDepartment of Microbiology, Vardhman Mahaveer Medical College and Safdarjung Hospital, New Delhi, India.en_US
dc.identifier.citationCapoor MR, Nair D, Hasan AS, Aggarwal P, Gupta B. Typhoid fever: narrowing therapeutic options in India. The Southeast Asian Journal of Tropical Medicine and Public Health. 2006 Nov; 37(6): 1170-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34577
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2006_37_6/18-3738.pdfen_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Infective Agents --administration & dosageen_US
dc.subject.meshColony Count, Microbialen_US
dc.subject.meshDrug Resistance, Bacterialen_US
dc.subject.meshDrug Resistance, Multiple, Bacterialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshSalmonella typhi --drug effectsen_US
dc.subject.meshTyphoid Fever --diagnosisen_US
dc.titleTyphoid fever: narrowing therapeutic options in India.en_US
dc.typeJournal Articleen_US
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