Evaluation of efficacy and tolerability of Losartan and Ramipril combination in the management of hypertensive patients with associated diabetes mellitus in India (LORD Trial).

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dc.contributor.authorJoshi, Shashank Ren_US
dc.contributor.authorYeolekar, M Een_US
dc.contributor.authorTripathi, K Ken_US
dc.contributor.authorGiri, Jen_US
dc.contributor.authorMaity, A Ken_US
dc.contributor.authorChopda, Men_US
dc.contributor.authorGujarathi, Sen_US
dc.contributor.authorMaroli, Sen_US
dc.contributor.authorMaity, Aen_US
dc.contributor.author,en_US
dc.date.accessioned2004-03-08en_US
dc.date.accessioned2009-05-30T21:09:11Z
dc.date.available2004-03-08en_US
dc.date.available2009-05-30T21:09:11Z
dc.date.issued2004-03-08en_US
dc.description.abstractAIM: The study was conducted to evaluate efficacy and tolerability of fixed dose combination (FDC) of Losartan and Ramipril in the management of mild to moderate hypertensive Native Asian Indian patients with associated diabetes mellitus. The secondary objective was to evaluate the efficacy of the combination in reducing microalbuminuria. MATERIAL AND METHODS: The study was an open, non-comparative, multicentric clinical trial conducted in seven Indian centres in 315 eligible patients. All the patients were treated with Losartan 50 mg + Ramipril 2.5 mg or Losartan 50 mg + Ramipril 5 mg once a day in 12 weeks and consisted of a total of eight visits. RESULTS: The mean age of patients was 52.93 years (range 45 - 60 years). Of the total patients, 62.86% were males and 37.14% were females. The mean prestudy systolic blood pressure was 160.56 +/- 14.44 which was significantly reduced to 126.85 +/- 9.78 at the end of 12 weeks (P < 0.001). Similarly the mean diastolic blood pressure was 98.91 +/- 8.33 at baseline (stage I) which was significantly reduced to 79.82 +/- 5.42 at the end of 12 weeks (P < 0.001). A mean fall of 33.72 mmHg in systolic blood pressure and the mean fall of 19.10 mmHg was observed in systolic and diastolic blood pressure respectively at the end of the treatment which was statistically highly significant (P < 0.001). The JNC-VII goal of blood pressure < 130/80 was achieved in 79.05% patients after the treatment which losartan and ramipril combination only. Microalbuminuria (urinary albumin excretion > 30 but < 300 mg/day) was seen in 83/250 (33.2%) patients and 135 (54%) patients had clinical proteinuria (albuminuria) at baseline. At the end of the therapy 20.8% patients achieved normoalbuminuria. Good to excellent efficacy response was reported in 98.09% patients and 98.41% patients reported good to excellent tolerability to the treatment. CONCLUSION: The fixed dose combination of Losartan and Ramipril showed good to excellent efficacy response in 98.10% patients and achieved a target blood pressure of 130/80 mmHg in 79.05% patients in 12 weeks. The combination reduced the urinary albumin excretion in majority of the patients with microalbuminuria and proteinuria (the major marker of nephropathy).en_US
dc.description.affiliationAsian Health Care, Lilavati Hospital, Mumbai.en_US
dc.identifier.citationJoshi SR, Yeolekar ME, Tripathi KK, Giri J, Maity AK, Chopda M, Gujarathi S, Maroli S, Maity A, . Evaluation of efficacy and tolerability of Losartan and Ramipril combination in the management of hypertensive patients with associated diabetes mellitus in India (LORD Trial). Journal of the Association of Physicians of India. 2004 Mar; 52(): 189-95en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/88358
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAlbuminuria --drug therapyen_US
dc.subject.meshAntihypertensive Agents --administration & dosageen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshComorbidityen_US
dc.subject.meshDiabetic Angiopathies --complicationsen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension --complicationsen_US
dc.subject.meshLosartan --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRamipril --administration & dosageen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEvaluation of efficacy and tolerability of Losartan and Ramipril combination in the management of hypertensive patients with associated diabetes mellitus in India (LORD Trial).en_US
dc.typeClinical Trialen_US
dc.typeClinical Trial, Phase IVen_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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