Biochemical Markers in Perinatal Asphyxia.

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dc.contributor.authorNaithani, M
dc.contributor.authorSimalti, A K
dc.date.accessioned2013-07-09T09:58:50Z
dc.date.available2013-07-09T09:58:50Z
dc.date.issued2011-05
dc.description.abstractEarly assessment of the severity of an acute cerebral lesion secondary to hypoxia-ischemia or other pathologic conditions may provide a very useful basis for preventive or therapeutic decisions in pediatric patients. In the present review, we discuss the diagnostic and prognostic value of a series of biochemical parameters, with special reference to the diagnosis of neonatal HIE. Currently many specific biochemical markers of brain injury are being investigated to assess regional brain damage after perinatal asphyxia in neonates of which serum protein S-100β, brain-specific creatine kinase, neuron-specific enolase, IL6 and urinary uric acid levels appear promising in identifying patients with a risk of developing hypoxic-ischemic encephalopathy. Whether detection of elevated serum concentrations of these proteins reflects long-term neurodevelopmental impairment remains to be investigated.en_US
dc.identifier.citationNaithani M, Simalti A K. Biochemical Markers in Perinatal Asphyxia. Journal of Nepal Paediatric Society. 2011 May-Aug; 31(2): 151-156.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147177
dc.language.isoenen_US
dc.source.urihttps://www.nepjol.info/index.php/JNPS/article/view/4155/3860en_US
dc.subjectS-100en_US
dc.subjectBrain specific creatine kinaseen_US
dc.subjectneuron specific enolaseen_US
dc.subjectIL6en_US
dc.subjecturinary uric aciden_US
dc.subjecthypoxic ischaemic cerebral injuryen_US
dc.titleBiochemical Markers in Perinatal Asphyxia.en_US
dc.typeArticleen_US
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