Lipoprotein(a) as a marker of coronary artery disease and its association with dietary fat.

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dc.contributor.authorBurman, Archanaen_US
dc.contributor.authorJain, Kajalen_US
dc.contributor.authorGulati, Ren_US
dc.contributor.authorChopra, Ven_US
dc.contributor.authorAgarwal, D Pen_US
dc.contributor.authorVasisht, Sen_US
dc.date.accessioned2004-02-20en_US
dc.date.accessioned2009-05-30T23:35:41Z
dc.date.available2004-02-20en_US
dc.date.available2009-05-30T23:35:41Z
dc.date.issued2004-02-20en_US
dc.description.abstractOBJECTIVE: The main objectives of the study were to evaluate the effect of dietary fat on plasma lipoprotein(a) [Lp(a)] levels and to study the potential of Lp(a) as a more reliable marker for CAD compared to other lipids and lipoproteins. METHODS: Twenty CAD patients and 20 healthy controls were recruited for the study. Their fasting plasma Lp(a) levels and complete lipid profile were assayed. The fat intake was calculated using 24 hours dietary recall method. The patients and controls were each divided into two subgroups: Group A consuming dietary fat > 30% and Group B consuming dietary fat < or = 30% of the total kilo-calories/day. RESULTS: Results indicated that plasma Lp(a), total serum cholesterol (TC), tryglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and LDL-C/HDL-C ratio of CAD patients were significantly higher than the controls. High fat intake was found to be associated with higher plasma Lp(a) levels (p<0.05) in patients only. No significant correlation was found between Lp(a) levels and other conventional lipoproteins. CONCLUSION: The lack of correlation between Lp(a) and other lipoproteins indicates its potential as an independent risk factor for CAD. High fat intake led to higher plasma Lp(a) levels in patients; hence it would be worthwhile to evaluate the effect of quality and quantity of fat intake on plasma Lp(a) levels in a larger sample size.en_US
dc.description.affiliationDepartment of Biochemistry, Institute of Home Economics, Delhi University, New Delhi, India.en_US
dc.identifier.citationBurman A, Jain K, Gulati R, Chopra V, Agarwal DP, Vasisht S. Lipoprotein(a) as a marker of coronary artery disease and its association with dietary fat. Journal of the Association of Physicians of India. 2004 Feb; 52(): 99-102en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/90562
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Distributionen_US
dc.subject.meshBiological Markers --analysisen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCholesterol, HDL --analysisen_US
dc.subject.meshCholesterol, LDL --analysisen_US
dc.subject.meshCoronary Disease --epidemiologyen_US
dc.subject.meshDietary Fats --adverse effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshLipoprotein(a) --analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProbabilityen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSex Distributionen_US
dc.subject.meshSurvival Rateen_US
dc.titleLipoprotein(a) as a marker of coronary artery disease and its association with dietary fat.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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