Pharmacologic bronchodilation response to salbutamol in COPD patients.
dc.contributor.author | Boskabady, Morteza | |
dc.contributor.author | Boskabady, Mohammad Hossein | |
dc.contributor.author | Mansouri, Fariba | |
dc.contributor.author | Shafei, Mohammad Naser | |
dc.date.accessioned | 2013-03-11T10:00:45Z | |
dc.date.available | 2013-03-11T10:00:45Z | |
dc.date.issued | 2010-08 | |
dc.description.abstract | Background: Airway hyperresponsiveness (AHR) is the most characteristic feature of asthma, which is reported in COPD patients and smokers. Increased airway responsiveness to ί-agonists is also demonstrated in asthmatics as well as smokers. However, there is no report regarding AHR to ί-agonist drugs in COPD patients. Therefore, in this study pharmacologic bronchodilation response to salbutamol in COPD patients was examined. Materials and Methods: The threshold concentrations of inhaled salbutamol required for a 20% change in forced expiratory flow in 1 sec (FEV 1 ) as PC 20 , or a 35% change in specific airway conductance (sGaw) as PC 35 was measured in 14 COPD patients and 14 normal subjects. Results: Airway responsiveness to salbutamol in COPD patients (PC 20 = 14.14 ± 1.62 and PC 35 = 9.70 ± 1.48 mg/l) was significantly lower than normal subjects (PC 20 = 224.57 ± 16.62 and PC 35 = 81.87 ± 8.16 mg/l, P < 0.001 for both cases). The values of FEV 1 and sGaw in COPD patients (56.43 ± 14.45 and 0.081 ± 0.120 respectively) were significantly lower than those of normal subjects (104.07 ± 5.72 and 0.194 ± 0.041 respectively), (P < 0.001 for FEV 1 and P < 0.005 for sGaw). There was a significant correlation between FEV 1 with PC 20 salbutamol (r = 0.862, P < 0.001). The correlations between PC 20 and PC 35 was also statistically significant (r = 0.862, P < 0.001). Conclusion: These results showed increased airway responsiveness of most COPD patients to salbutamol which was highly correlated to airway caliber. | en_US |
dc.identifier.citation | Boskabady Morteza, Boskabady Mohammad Hossein, Mansouri Fariba, Shafei Mohammad Naser. Pharmacologic bronchodilation response to salbutamol in COPD patients. Indian Journal of Medical Sciences. 2010 Aug; 64(8) 363-372. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/145554 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2010;volume=64;issue=8;spage=363;epage=372;aulast=Boskabady | en_US |
dc.subject | Airway caliber | en_US |
dc.subject | airway responsiveness | en_US |
dc.subject | COPD | en_US |
dc.subject | salbutamol | en_US |
dc.subject | smoker | en_US |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Airway Remodeling --drug effects | |
dc.subject.mesh | Airway Resistance --dug effects | |
dc.subject.mesh | Albuterol --pharmacokinetics | |
dc.subject.mesh | Albuterol --pharmacology | |
dc.subject.mesh | Anti-Asthmatic Agents --pharmacology | |
dc.subject.mesh | Anti-Asthmatic Agents --therapeutic use | |
dc.subject.mesh | Asthma --drug therapy | |
dc.subject.mesh | Asthma --physiopathology | |
dc.subject.mesh | Bronchi --drug effects | |
dc.subject.mesh | Bronchi --pharmacology | |
dc.subject.mesh | Bronchi --physiology | |
dc.subject.mesh | Bronchial Hyperreactivity --pharmacology | |
dc.subject.mesh | Bronchodilator Agents --pharmacokinetics | |
dc.subject.mesh | Bronchodilator Agents --pharmacology | |
dc.subject.mesh | Patients | |
dc.subject.mesh | Pulmonary Disease, Chronic Obstructive --drug therapy | |
dc.subject.mesh | Smoking --adverse effects | |
dc.subject.mesh | Smoking --complications | |
dc.subject.other | Bronchial Hyperreactivity --physiopathology | |
dc.title | Pharmacologic bronchodilation response to salbutamol in COPD patients. | en_US |
dc.type | Article | en_US |