Acyclovir is not effective in pityriasis rosea: Results of a randomized, triple-blind, placebo-controlled trial.

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dc.contributor.authorSingh, Sanjay
dc.contributor.authorAnurag
dc.contributor.authorTiwary, Narendra K
dc.date.accessioned2016-11-15T11:21:17Z
dc.date.available2016-11-15T11:21:17Z
dc.date.issued2016-09
dc.description.abstractBackground: Acyclovir is considered to be an effective treatment for pityriasis rosea but randomized, blinded, placebo-controlled trials have not been performed. Aims: To test the efficacy of acyclovir in pityriasis rosea in a randomized, triple–blind, placebo-controlled trial. Methods: Twenty seven patients with pityriasis rosea were randomly allocated to receive placebo (n = 13) or acyclovir (800 mg fi ve times daily for one week) (n = 14). The severity of disease was assessed by the pityriasis rosea area and severity index. Cure was defi ned as the absence of erythema, with no or minimal scaling. Results: The number of days (mean ± standard deviation) taken for cure was not signifi cantly different between the two groups (placebo 26.54 ± 9.14 days versus acyclovir 33.29 ± 9.49 days; P = 0.0720, t-test; 95% confi dence interval of difference −0.65 to 14.14 days). Limitations: The sample size for the present study was calculated using data from an earlier study. As the standard deviation was not mentioned in that article, a common standard deviation of fi fteen days was assumed. A study with a larger sample size may be more effective in detecting minor treatment differences between acyclovir and placebo, if they exist at all. Conclusion: Acyclovir is not an effective treatment for pityriasis rosea.en_US
dc.identifier.citationSingh Sanjay, Anurag, Tiwary Narendra K. Acyclovir is not effective in pityriasis rosea: Results of a randomized, triple-blind, placebo-controlled trial. Indian Journal of Dermatology, Venereology and Leprology. 2016 Sept-Oct; 82(5): 505-509.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/178461
dc.language.isoenen_US
dc.source.urihttps://www.ijdvl.com/article.asp?issn=0378-6323;year=2016;volume=82;issue=5;spage=505;epage=509;aulast=Singhen_US
dc.subjectAcycloviren_US
dc.subjectpityriasis roseaen_US
dc.subjectrandomized controlled trialen_US
dc.titleAcyclovir is not effective in pityriasis rosea: Results of a randomized, triple-blind, placebo-controlled trial.en_US
dc.typeArticleen_US
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