Management of Hepatitis C in Children – A New Paradigm

Simple item page
dc.contributor.authorPoddar, Ujjalen_US
dc.contributor.authorReddy, DV Umeshen_US
dc.date.accessioned2023-08-25T06:40:00Z
dc.date.available2023-08-25T06:40:00Z
dc.date.issued2023-01
dc.description.abstractIntroduction: With the advent of direct-acting antivirals (DAAs), the past decade has seen a paradigm shift in the management of hepatitis C (HCV) infection in children. In this review, we summarize the various treatment options for pediatric HCV infection, highlighting the recent changes in the management. Methods: A literature search was performed using the PubMed database with the relevant keywords. Filters included were human, ages 0-18 years, and the English language. Results: Initial phase of HCV treatment using conventional or pegylated interferon and ribavirin combination regimens yielded poor outcomes in children, especially in genotypes 1 and 4, with an overall sustained virologic response of 58%. Also, treatment with interferon and ribavirin combination was associated with significant side effects in up to 52% of those treated. Presently, various combinations of direct-acting antivirals (DAAs) have been approved in children above three years of age with documented evidence of high efficacy (SVR12 of 92% to 100%) and excellent safety, and the current standard of care. Conclusion: With various DAA regimens now being approved for children above three years of age, the treatment of active HCV infection (HCV-RNA positive) in children has become simple. Besides the effectiveness of DAA therapy, public awareness about HCV transmission, better screening, and making the DAAs available at a subsidized price in the public sectors are necessary to eliminate HCV infection in India.en_US
dc.identifier.affiliationsDepartments of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradeshen_US
dc.identifier.affiliationsDepartment of Pediatric Gastroenterology, Post Graduate Institute of Child Health Hospital, Noida, Uttar Pradesh.en_US
dc.identifier.citationPoddar Ujjal, Reddy DV Umesh. Management of Hepatitis C in Children – A New Paradigm. Indian Pediatrics. 2023 Jan; 60(1): 55-62en_US
dc.identifier.issn0079-6061
dc.identifier.issn0974-7559
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225457
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber1en_US
dc.relation.volume60en_US
dc.source.urihttps://indianpediatrics.net/jan2023/55.pdfen_US
dc.subjectDirect-acting antiviralsen_US
dc.subjectInterferonen_US
dc.subjectOutcomeen_US
dc.subjectRibavirin.en_US
dc.titleManagement of Hepatitis C in Children – A New Paradigmen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IP2023v60n1p55.pdf
Size:
162.45 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Pediatrics