Effects of isolated compound from Sonneratia caseolaris leaf: a validation of traditional utilization by melanin biosynthesis and antioxidant assays.

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dc.contributor.authorArung, Enos Tangke
dc.contributor.authorKuspradini, Harlinda
dc.contributor.authorKusuma, Irawan Wijaya
dc.contributor.authorBang, Tran Hai
dc.contributor.authorYamashita, Shuntaro
dc.contributor.authorKatakura, Yoshinori
dc.contributor.authorShimizu, Kuniyoshi
dc.date.accessioned2015-11-30T06:09:28Z
dc.date.available2015-11-30T06:09:28Z
dc.date.issued2015-10
dc.description.abstractIn continuing to search new materials for skin whitening agent from natural resources, we have focused on plants used by Dayak tribe (native people in East Kalimantan, Indonesia) for skin care treatment. The ethanol extract of the leaves of Sonneratia caseolaris showed anti-melanogenesis activity in melanin biosynthesis assays using B16 melanoma cells. By activity-guided fractionation, luteolin-7-O--glucoside (compound 1) was isolated as an active compound. In melanin formation inhibition assay, luteolin-7-O--glucoside showed the inhibitory activity in a dose-dependent manner and reach 44% of inhibition at 223.2 μM with 92% of cells viability. The compound also showed potent anti-oxidative stress ability with a significant intracellular H2O2-scavenging activity in HaCaT cells. These results showed a validation of traditional use for skin care treatment by Dayak tribe in East Kalimantan.en_US
dc.identifier.citationArung Enos Tangke, Kuspradini Harlinda, Kusuma Irawan Wijaya, Bang Tran Hai, Yamashita Shuntaro, Katakura Yoshinori, Shimizu Kuniyoshi. Effects of isolated compound from Sonneratia caseolaris leaf: a validation of traditional utilization by melanin biosynthesis and antioxidant assays. Journal of Applied Pharmaceutical Science. 2015 Oct; 5(10): 39-43.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/166561
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/abstract.php?article_id=1649en_US
dc.subjectSonneratia caseolarisen_US
dc.subjectmelanin biosynthesisen_US
dc.subjectH2O2-scavengingen_US
dc.subjectB16 melanoma cellsen_US
dc.subjectluteolin-7-O-ß-glucosideen_US
dc.titleEffects of isolated compound from Sonneratia caseolaris leaf: a validation of traditional utilization by melanin biosynthesis and antioxidant assays.en_US
dc.typeArticleen_US
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