Atrial Function and Glutathione in Children with Iron Deficiency Anemia- Tanta-Egypt-2012.

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dc.contributor.authorBiltagi, Mohammed Al
dc.contributor.authorTolba, Osama
dc.contributor.authorElshanshory, Mohammed
dc.contributor.authorBadraia, Ibrahim
dc.contributor.authorHazaa, Sahar M
dc.date.accessioned2014-08-09T08:38:25Z
dc.date.available2014-08-09T08:38:25Z
dc.date.issued2013-07
dc.description.abstractAims: is to correlate the atrial function with the level of oxidative stress marker (Glutathione) in children with Iron deficiency anemia (IDA). Materials and Methods: Thirty children with IDA and 20 healthy children had serum Ferritin, total blood Glutathione level and studied with conventional trans-thoracic 2-D echocardiography, Tissue Doppler (TDI) and Speckle Tracking Strain (STI) analysis. Study Design: A case–controlled study Place and Duration of Study: Pediatric Outpatient Clinic; Pediatric Hematology Unit; Pediatric Cardiology Unit; Pediatric Department; Faculty of Medicine; Tanta University Hospital; Egypt. The study was conducted between January; 2012 to December; 2012. Results: Children with IDA had significantly low Glutathione [4.63 ±3.4 ng/ml] (P =.013) and Ferritin [11.88 ±5.3 ng/ml] (P < .0001) levels than that observed in the control group. There was no significant increase in LA dimension and volume (minimum) [31± 27 ml] (P = .433), by M-mode but there was significant decrease in e/a ratio assessed by tissue Doppler in IDA patients [1.29 ±0.5] than in controls [1.6±0.7] (P = .038). There were significant decrease in LA velocity (P = .02) and increase in RA velocity (P = .04) compared to left atrial and atrial septal velocity and insignificant increase in left atrial velocity compared to atrial septal velocity. There was no significant correlation between Glutathione level and echo-Doppler parameters of atrial function (P >.05), but there was significant negative correlation between Hemoglobin% and atrial septal velocity (P < .05). Conclusion: IDA is associated with diastolic dysfunction. Tissue Doppler and STI were more sensitive than conventional echocardiography in detection of subclinical structural and functional changes due to hemodynamic abnormality in children with IDA.en_US
dc.identifier.citationBiltagi Mohammed Al, Tolba Osama, Elshanshory Mohammed, Badraia Ibrahim, Hazaa Sahar M. Atrial Function and Glutathione in Children with Iron Deficiency Anemia- Tanta-Egypt-2012. International Blood Research & Reviews. 2013 Jul-Dec: 1 (2): 72-86.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/153591
dc.language.isoenen_US
dc.source.urihttps://www.sciencedomain.org/abstract.php?iid=255&id=28&aid=1924en_US
dc.subjectIron deficiency anemiaen_US
dc.subjectglutathioneen_US
dc.subjectoxidative stress markersen_US
dc.subjectatrial functionen_US
dc.subjectechocardiographyen_US
dc.titleAtrial Function and Glutathione in Children with Iron Deficiency Anemia- Tanta-Egypt-2012.en_US
dc.typeArticleen_US
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