Multiorgan dysfunction syndrome in sickle cell disease.

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dc.contributor.authorHiran, Sujataen_US
dc.date.accessioned2005-01-29en_US
dc.date.accessioned2009-05-30T22:56:18Z
dc.date.available2005-01-29en_US
dc.date.available2009-05-30T22:56:18Z
dc.date.issued2005-01-29en_US
dc.description.abstractOBJECTIVE: Concurrent failure of multiple organs in patients of sickle cell disease (SCD) has rarely been reported. The main objective of this study was to highlight the multiorgan dysfunction (MODS) that occurs in some patients during sickle cell crisis. METHODS: Ten episodes of multiorgan failure were identified with sickle cell disease and defining criteria of organ failure of two or more organs that is lung, liver, or renal were established according to Acute Physiological and Chronic Health Evaluation - II (APACHE-II) criteria. RESULTS: Most episodes occurred during vaso-occlusive crisis, which was associated with a severe pain event. The onset of organ failure was associated with fever, rapid fall in haematocrit, platelet count and altered sensorium, later organ failure set in. Respiratory, hepatic, and kidney failure (all the three organs) were present in three of the ten patients who were in sickle crisis. Of this we lost one patient despite exchange transfusion and ventilator support. Of the four patients who had respiratory failure accompanied by hepatic failure, one patient died due to associated septicemia. Respiratory failure with renal involvement was seen in two patients whereas hepatic and renal failure was present in only one patient. Except for two, all other patients improved after aggressive blood transfusions. CONCLUSION: Acute multiorgan failure is a life threatening complication of SCD, which can exhibit without any evidence of chronic organ damage and is easily reversed by prompt and aggressive transfusion therapy.en_US
dc.description.affiliationDepartment of Medicine, JLN Hospital and Research Centre, Bhilai.en_US
dc.identifier.citationHiran S. Multiorgan dysfunction syndrome in sickle cell disease. Journal of the Association of Physicians of India. 2005 Jan; 53(): 19-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/89976
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshAnemia, Sickle Cell --complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMultiple Organ Failure --etiologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSyndromeen_US
dc.titleMultiorgan dysfunction syndrome in sickle cell disease.en_US
dc.typeJournal Articleen_US
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