Changes in Platelet Indices in Obese and Non-Obese Individuals in a Tertiary Healthcare Facility in Uyo, Nigeria
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Date
2019-10
Journal Title
Journal ISSN
Volume Title
Publisher
International Journal of Medical and Health Sciences
Abstract
Background: Obesity is associated with significant cardiovascular and thromboembolic risk largely due to increased plateletreactivity. Objectives: To determine the changes in platelet counts and platelet activation using platelet indices (MPV & PDW) inobese and non-obese patients in a tertiary hospital in Uyo, Nigeria.Methodology: This was a cross-sectional descriptive studycomprising of 191 participants recruited consecutively from the out-patients Departments of University of Uyo Teaching Hospitalover a six months period (March-August 2018). Patients were categorised into obese, overweight and normal weight based ontheir Body Mass Index (BMI). Also, 2.5mls of blood was collected from each patient and same was used to determine full bloodcount from where the platelet count and platelet indices (MPV & PDW) were obtained. Results: There was progressive increasein the mean platelet count of the patients (210.59 ± 51.6, 194.26 ± 49.8, 184.95 ± 51.7 for obese, overweight and normal weightrespectively) and this increase was statistically significant (P=0.0208). However, the mean platelet indices (MPV & PDW) wasnot statistically significant (P=0.351 and 0.933 for MPV and PDW respectively). Conclusion: Platelet counts was significantlyelevated in obese patients compared with the overweight and normal weight however, the MPV and PDW was not significantlydifferent in the three groups.
Description
Keywords
Obesity, Body mass Index, Platelet indices, Platelet activation.
Citation
Ekwere Timothy Amos, OlugbemiOluseyiMotilewa. Changes in Platelet Indices in Obese and Non-Obese Individuals in a Tertiary Healthcare Facility in Uyo, Nigeria. International Journal of Medical and Health Sciences . 2019 Oct; 8(4): 53-57