Neuroprotective Effect of Cinamomum zeylanicum in streptozotocin induced diabetes in Mice
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Date
2016-01
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Abstract
Background: Diabetes is recognized as one of the leading causes of morbidity and mortality &
representing as an emerging global epidemic worldwide. Diabetes and stroke both are the conditions
which share various common threats. A patient with Diabetes has higher risk of stroke as compared to
non Diabetics. Diabetes and stroke both affects the blood vessels. There are several biochemical
pathways which are responsible for the developments of vascular complications due to hyperglycemia.
Thus prevention and treatment of diabetes and stroke can reduce the risk of various vascular diseases.
Cinnamomum zeylanicum has been used for the treatment of diabetes since long time. Cinnamomum
zeylanicum rich in phenolic contents (antioxidants) have been identified as a major active component
exhibiting antioxidant, and neuroprotective effects. The present study evaluate the neuroprotective effect
of Cinnamomum zeylanicum in streptozotocin induced diabetes in mice and experimentally induced
global cerebral ischemia/reperfusion injury in mice. Materials and methods: Swiss albino mice (male)
weighing 20-30 g were randomized into eight groups. Diabetes was induced by administering
streptozotocin (65 mg/kg, i.p).Starting from seven days after streptozotocin injection, insulin and
Cinnamomum zeylanicum were administered for 3 weeks. Serum glucose level and body weight were
measured weekly. Neuroprotective activity was carried out by global cerebral ischemia on swiss albino
mice by carotid artery occlusion for 10 min followed by 24 hr. reperfusion. Measurement of
Triglycerides, Malondialdehyde , cerebral infarct size and glutathione level was carried out at the end of
the study. Results: After 21 days of treatment with Cinnamomum zeylanicum (75 mg/kg, 150 mg/kg and
300 mg/kg, p.o) significant increase in body weight and glutathione level and a significant reduction in
serum glucose level, triglycerides, MDA levels and cerebral infarct size was observed as compared to
diabetic control and diabetic+ stroke group. Conclusion: The present study concludes that Polyphenolic
fraction of Cinnamomum zeylanicum not only attenuates the diabetes but also reverse the cerebral
infarction in mice through its neuroprotective actions and thus Cinnamomum zeylanicum may serves as
a new therapeutic alternative for management of brain damage associated with type-1 diabetes
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Keywords
Diabetes mellitus, Hyperglycemia, Oxidative stress, Cinnamomumzeylanicum, Streptozotocin
Citation
Joshi Vandana , Kumar Arun, Kothiyal Preeti. Neuroprotective Effect of Cinamomum zeylanicum in streptozotocin induced diabetes in Mice. Indian Journal of Pharmaceutical & Biological Research. 2016 Jan-Mar; 4(1): 63-73.