Pathology of temporal lobe epilepsy: An analysis of 100 consecutive surgical specimens from patients with medically refractory epilepsy.

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dc.contributor.authorRadhakrishnan, V Ven_US
dc.contributor.authorRao, M Ben_US
dc.contributor.authorRadhakrishnan, Ken_US
dc.contributor.authorThomas, S Ven_US
dc.contributor.authorNayak, D Sen_US
dc.contributor.authorSantoshkumar, Ben_US
dc.contributor.authorJoseph, Een_US
dc.contributor.authorRaghunath, Ben_US
dc.date.accessioned1999-09-09en_US
dc.date.accessioned2009-06-03T10:55:42Z
dc.date.available1999-09-09en_US
dc.date.available2009-06-03T10:55:42Z
dc.date.issued1999-09-09en_US
dc.description.abstractThe neuropathological features of temporal lobe epilepsy were studied utilising 100 consecutive surgical specimens from patients with medically refractory complex partial seizures. A wide spectrum of neuropathological changes was recorded in 98 specimens. Fifty-eight specimens showed features of Ammon's horn sclerosis. Diffuse accumulation of corpora amylacea were demonstrated in the resected temporal lobes from 54 patients. Six patients had neoplastic lesions of temporal lobe. One unique case of dysembryoplastic neuroepithelial tumour showed a melanotic component within the tumour. The neuropathological features were regarded as nonspecific in 31% of cases. Our results indicate that a majority of patients with medically intractable epilepsy of temporal lobe origin reveal significant neuropathological features. Careful documentation of the neuropathological features and its correlation with radiological, electrophysiological and pre- and post-surgical clinical features will help in predicting the seizure outcome after temporal lobectomy for medically refractory epilepsy.en_US
dc.description.affiliationDepartment of Pathology, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala, 695011, India.en_US
dc.identifier.citationRadhakrishnan VV, Rao MB, Radhakrishnan K, Thomas SV, Nayak DS, Santoshkumar B, Joseph E, Raghunath B. Pathology of temporal lobe epilepsy: An analysis of 100 consecutive surgical specimens from patients with medically refractory epilepsy. Neurology India. 1999 Sep; 47(3): 196-201en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/120548
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshBrain Neoplasms --pathologyen_US
dc.subject.meshEpilepsy, Temporal Lobe --pathologyen_US
dc.subject.meshHippocampus --pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshSclerosisen_US
dc.subject.meshTemporal Lobe --pathologyen_US
dc.titlePathology of temporal lobe epilepsy: An analysis of 100 consecutive surgical specimens from patients with medically refractory epilepsy.en_US
dc.typeJournal Articleen_US
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