Effects of combined sildenafil-nitric oxide donor on defibrillation efficacy.
dc.contributor.author | Shinlapawittayatorn, Krekwit | en_US |
dc.contributor.author | Chattipakorn, Siriporn | en_US |
dc.contributor.author | Sungnoon, Rattapong | en_US |
dc.contributor.author | Chattipakorn, Nipon | en_US |
dc.date.accessioned | 2009-05-27T20:16:43Z | |
dc.date.available | 2009-05-27T20:16:43Z | |
dc.date.issued | 2007-10-29 | en_US |
dc.description | Chotmaihet Thangphaet. | en_US |
dc.description.abstract | BACKGROUND: A previous study demonstrated that supra-therapeutic concentration of sildenafil citrate attenuates defibrillation efficacy. However, the effect of combined sildenafil and NTG administration on defibrillation efficacy is not known. OBJECTIVE: The present study investigated whether sildenafil administration at the therapeutic level increases the defibrillation threshold (DFT) when combined with NTG. MATERIAL AND METHOD: Twenty-four pigs (20-25 kg) were randomized into four groups. After the control DFT was obtained, a stock solution of 50-mg (group 1, therapeutic concentration) and 100-mg (group 2, supratherapeutic concentration) of sildenafil, and 100-mL of saline (groups 3 and 4) were infused at 2 mL/min. Then, NTG was administered in groups 1-3 at 5 microg/min, with an increment of 5 microg/min every 5 min. The DFT was determined again after NTG was infused for 20 minutes. RESULTS: In group 1, the DFT (402 +/- 33V, 11 +/- 2J) was not different from the control (404 +/- 28V, 11 +/- 2J). In group 2, the DFT (521 +/- 18V, 19 +/- 1J) was higher (p < 0.004) than that in the control group (444 +/- 31V, 14 +/- 2J). Saline did not alter the DFT either individually or in combination with NTG. CONCLUSION: Supratherapeutic dose of sildenafil-NTG combination significantly increased the DFT (17% of peak voltage, 37% of total energy). This effect on DFT appears to be driven by sildenafil and not NTG. | en_US |
dc.description.affiliation | Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. | en_US |
dc.identifier.citation | Shinlapawittayatorn K, Chattipakorn S, Sungnoon R, Chattipakorn N. Effects of combined sildenafil-nitric oxide donor on defibrillation efficacy. Journal of the Medical Association of Thailand. 2007 Oct; 90(10): 2143-9 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/42700 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.mat.or.th/journal/all.php | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Electric Countershock | en_US |
dc.subject.mesh | Heart Ventricles --drug effects | en_US |
dc.subject.mesh | Hemodynamics --drug effects | en_US |
dc.subject.mesh | Myocardium | en_US |
dc.subject.mesh | Nitric Oxide --pharmacology | en_US |
dc.subject.mesh | Nitroglycerin --pharmacology | en_US |
dc.subject.mesh | Phosphodiesterase Inhibitors --pharmacology | en_US |
dc.subject.mesh | Piperazines --pharmacology | en_US |
dc.subject.mesh | Purines --pharmacology | en_US |
dc.subject.mesh | Sulfones --pharmacology | en_US |
dc.subject.mesh | Swine | en_US |
dc.subject.mesh | Ventricular Fibrillation --physiopathology | en_US |
dc.title | Effects of combined sildenafil-nitric oxide donor on defibrillation efficacy. | en_US |
dc.type | Journal Article | en_US |
dc.type | Research Support, Non-U.S. Gov't | en_US |
Files
License bundle
1 - 1 of 1