Neuroprotective Effects of P-Coumaric Acid on Haloperidol-Induced Catalepsy Through Ameliorating Oxidative Stress and Brain Dopamine Level

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dc.contributor.authorPathan, ASen_US
dc.contributor.authorJain, PGen_US
dc.contributor.authorKumawat, VSen_US
dc.contributor.authorKatolkar, UNen_US
dc.contributor.authorSurana, SJ.en_US
dc.date.accessioned2023-06-17T07:13:05Z
dc.date.available2023-06-17T07:13:05Z
dc.date.issued2023-02
dc.description.abstractObjective To evaluate the effect of p-coumaric acid (p-CA) on haloperidol-induced catalepsy in Swiss albino male mice. Method To induce catalepsy, haloperidol (1 mg/kg i.p.) was administered for 21 consecutive days. p-CA (50, 75, and 100 mg/kg, PO) was administered 30 min before haloperidol injection for 21 consecutive days. For catalepsy, locomotor activity and motor coordination scores were recorded on the 17, 14, and 21 days of drug treatment, while the gait analysis score was recorded on day 21. After behavioral testing, animals were sacrificed, and various biochemical and histopathology tests of the brain were conducted. Dopamine, malondialdehyde, reduced glutathione (GSH), superoxide dismutase (SOD), and catalase activity were examined in the brain. Results Chronic administration of haloperidol significantly increased catalepsy in mice. It also produced hypolocomotion, motor coordination, and gait disturbance in mice. p-CA significantly inhibited haloperidol-induced catalepsy. Haloperidol significantly increased malondialdehyde levels in the brain. While dopamine levels in the brain dropped along with GSH, SOD, and catalase activity levels, which also had an impact on the histology of the brain. p-CA significantly reduced haloperidol-induced increases in brain oxidative stress, dopamine levels in the brain, and brain histology in mice. Discussion p-CA significantly reduced haloperidol-induced catalepsy, possibly through reducing oxidative stress and increasing brain dopamine levels. It can be a good candidate drug for extrapyramidal symptoms in Parkinson’s disease and adjuvant therapy with antipsychotic drugs.en_US
dc.identifier.affiliationsDepartment of Pharmacology, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, India.en_US
dc.identifier.citationPathan AS, Jain PG, Kumawat VS, Katolkar UN, Surana SJ.. Neuroprotective Effects of P-Coumaric Acid on Haloperidol-Induced Catalepsy Through Ameliorating Oxidative Stress and Brain Dopamine Level. Journal of Pharmacology and Pharmacotherapeutics. 2023 Feb; 13(4): 364–374en_US
dc.identifier.issn0976-500X
dc.identifier.issn0976-5018
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216081
dc.languageenen_US
dc.publisherSAGE Publicationsen_US
dc.relation.issuenumber4en_US
dc.relation.volume13en_US
dc.source.urihttps://doi.org/10.1177/0976500X221150837en_US
dc.subjectp-coumaric aciden_US
dc.subjectcatalepsyen_US
dc.subjectlocomotor activityen_US
dc.subjectmotor impairmenten_US
dc.subjectoxidative stressen_US
dc.subjectdopamineen_US
dc.subjectmiceen_US
dc.titleNeuroprotective Effects of P-Coumaric Acid on Haloperidol-Induced Catalepsy Through Ameliorating Oxidative Stress and Brain Dopamine Levelen_US
dc.typeJournal Articleen_US
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