Auditory brainstem responses (ABR) in neonates with hyperbilirubinemia.

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dc.contributor.authorGupta, A Ken_US
dc.contributor.authorRaj, Hen_US
dc.contributor.authorAnand, N Ken_US
dc.date.accessioned1990-09-01en_US
dc.date.accessioned2009-05-30T10:53:41Z
dc.date.available1990-09-01en_US
dc.date.available2009-05-30T10:53:41Z
dc.date.issued1990-09-01en_US
dc.description.abstractThe technique of ABR testing was applied to 25 infants with neonatal hyperbilirubinemia at levels exceeding that for exchange transfusion, in an attempt to study potential influence of bilirubin toxicity on the auditory brainstem pathway. The test was performed at a mean conceptional age of 40.4 +/- 0.6 weeks just after discharge. Twenty normal term neonates of comparable birth weights and conceptional ages, who had no hyperbilirubinemia, were also examined for comparison. Fifty six percent (n = 14) of the hyperbilirubinemic neonates had some abnormality in the ABR pattern, the major one being a transient increase in the threshold of wave V (7, fail-30; 5, fail-45). Wave V, however, was consistently present at 30 dBnHL click stimulus in all the normal neonates (pass-30; normal threshold). Further, mean ABR latencies (wave III, V) and 1-V interpeak latency (brainstem conduction time) were significantly prolonged in jaundiced neonates as compared with controls (P less than 0.01). ABR changes were strongly correlated with the serum bilirubin levels (P less than 0.001). On follow up retesting at 3 months, however, all infants were found to have normal ABR latencies and threshold. Neonatal jaundice was associated with significant transient aberrations of ABR, suggestive of a transient toxic brainstem encephalopathy.en_US
dc.description.affiliationDepartment of Pediatrics, Safdarjang Hospital, New Delhi.en_US
dc.identifier.citationGupta AK, Raj H, Anand NK. Auditory brainstem responses (ABR) in neonates with hyperbilirubinemia. Indian Journal of Pediatrics. 1990 Sep-Oct; 57(5): 705-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/79117
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAuditory Threshold --physiologyen_US
dc.subject.meshEvoked Potentials, Auditory, Brain Stemen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHearing Disorders --physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperbilirubinemia --physiopathologyen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshRisk Factorsen_US
dc.titleAuditory brainstem responses (ABR) in neonates with hyperbilirubinemia.en_US
dc.typeJournal Articleen_US
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