Time-relative changes in the erythrocyte antioxidant enzyme activities and their relationship with Glasgow Coma Scale scores in severe head injury patients in the 21-day posttraumatic study period.

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dc.contributor.authorNayak, Chandrika Den_US
dc.contributor.authorNayak, Dinesh Men_US
dc.contributor.authorRaja, Annaswamyen_US
dc.contributor.authorRao, Anjalien_US
dc.date.accessioned2007-07-06en_US
dc.date.accessioned2009-05-29T04:47:00Z
dc.date.available2007-07-06en_US
dc.date.available2009-05-29T04:47:00Z
dc.date.issued2007-07-06en_US
dc.description.abstractBACKGROUND: Reactive oxygen species are indicated to play a prime role in the pathophysiology of brain damage following a severe head injury (SHI). AIM: The current study was designed to understand the time-relative changes and relationship between erythrocyte antioxidant enzyme activities and Glasgow Coma Scale (GCS) scores of SHI patients in the 21-day posttraumatic study period. SETTINGS AND DESIGN: The study included 24 SHI patients and 25 age- and sex-matched normal controls (NC). Activities of superoxide dismutase (SOD), glutathione reductase (GR) and glutathione peroxidase (GSH-Px) were assayed in these patients and controls. The GCS scores of these patients were also recorded for the comparative study. Materials and Methods: Venous blood samples were collected on day 7 (D7) and D21 from SHI patients and NC for the assay of SOD, GR and GSH-Px activities. These changes were correlated with age and changes in GCS scores of patients. STATISTICAL ANALYSIS: A one-way analysis of variance (ANOVA) was used to compare mean values of each parameter between group 1 (NC), group 2 (D7 changes in SHI patients) and group 3 (D21 changes in SHI patients). ANOVA was followed by Bonferroni post hoc tests. The Pearson correlation was applied to correlate between the antioxidant parameters and age and GCS scores of these patients. RESULTS: A significant increase in erythrocyte SOD and GSH-Px activities was observed in group 3 as compared to groups 1 and 2. The increase in GSH-Px activity was significant in group 2 as compared to group 1. Although not significant, there was an increase in mean GR activity in groups 2 and 3 as compared to group 1. CONCLUSION: These findings indicate that SHI patients have shown significantly enhanced erythrocyte SOD and GSH-Px activities during the 21-day posttraumatic study period.en_US
dc.description.affiliationDepartment of Biochemistry, Melaka Manipal Medical College (Manipal Campus), Manipal University, Manipal-576 104, India. chandrikadinesh@yahoo.comen_US
dc.identifier.citationNayak CD, Nayak DM, Raja A, Rao A. Time-relative changes in the erythrocyte antioxidant enzyme activities and their relationship with Glasgow Coma Scale scores in severe head injury patients in the 21-day posttraumatic study period. Indian Journal of Medical Sciences. 2007 Jul; 61(7): 381-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/66878
dc.language.isoengen_US
dc.source.urihttps://www.indianjmedsci.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAntioxidants --metabolismen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCraniocerebral Trauma --metabolismen_US
dc.subject.meshErythrocytes --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlasgow Coma Scaleen_US
dc.subject.meshGlutathione Peroxidaseen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshReactive Oxygen Speciesen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSickness Impact Profileen_US
dc.subject.meshTimeen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshWounds and Injuries --metabolismen_US
dc.titleTime-relative changes in the erythrocyte antioxidant enzyme activities and their relationship with Glasgow Coma Scale scores in severe head injury patients in the 21-day posttraumatic study period.en_US
dc.typeJournal Articleen_US
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