Mixed-species malaria infection in high transmission areas of Thailand

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dc.contributor.authorKanungnit Congpuongen_US
dc.contributor.authorJose Pedro Gilen_US
dc.contributor.authorPongwit Bualombaien_US
dc.contributor.authorYaowares Kangchaingoneen_US
dc.contributor.authorAmpai Darakapongen_US
dc.contributor.authorWalther H. Wernsdorferen_US
dc.date.accessioned2011-02-15T08:15:22Z
dc.date.available2011-02-15T08:15:22Z
dc.date.created2009-12-27en_US
dc.date.issued2009-12-27en_US
dc.description.abstractBackground: Mixed-species malaria infections examined by microscopy of Giemsa-stained thick blood films (GS-TBF) during 1996-2007 in Thailand were 0.3-0.5. However, there were reports of higher mixed-species infection rates detected by polymerase chain reaction (PCR) method. This study was conducted in order to ascertain the relative frequency of mixed-species malaria infection and possible determinants in top 10 malaria high transmission provinces of Thailand. Methods: This study was a survey of mixed Plasmodium species incidence in the top 10 malaria transmission provinces of Thailand. A total of 836 malaria patients were examined. The number of samples in each province was proportionate to the number of malaria patients in that province. A real-time PCR based on SYBR Green I detection system was used to detect and differentiate Plasmodium species. Results: Preliminary results from GS-TBF examined by the microscopists at the malaria clinics in the selected areas showed that 380 (45.5%) of 836 patients were infected by Plasmodium falciparum; 450 (53.8%), 2 (0.2%) and 4 (0.5%) were infected by P. vivax, P. malariae and mixed P. falciparum and P. vivax, respectively. Real-time PCR results of the corresponding samples from filter papers showed that 353 (42.2%) were infected by Plasmodium falciparum; 446 (53.4%), 1 (0.1%), 2 (0.2%), 32 (3.8%), 1 (0.1%) and 1 (0.1%) were infected by P. vivax, P. malariae, P. ovale, mixed P. falciparum and P. vivax, mixed P. falciparum and P. malariae and mixed P. vivax and P. ovale, respectively. Conclusion: Mixed-infection rates detected by real-time PCR were 8.48 (4.07/0.48) times higher than those detected by GS-TBS. Demographic factors including age, sex, occupation, place where contracted the disease and recurrence of the infection were not different between the groups with mono-species infection and mixed-species infection.en_US
dc.identifier.citationAsian Biomedicine (Research Reviews and News); Vol. 2 No. 2 April 2008; 117-121.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/129811
dc.language.isoen_USen_US
dc.publisherAsian Biomedicine (Research Reviews and News)en_US
dc.rightsAsian Biomedicine (Research Reviews and News)en_US
dc.source.urihttps://abm.digitaljournals.org/index.php/abm/article/viewFile/167/86en_US
dc.titleMixed-species malaria infection in high transmission areas of Thailanden_US
dc.typeOriginal articleen_US
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