Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma.
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Date
2016-01
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Abstract
Three histological subtypes of lymphomatoid papulosis (LyP), type A (histiocytic),
type B (mycosis fungoides like) and type C (anaplastic large cell lymphoma
like) are well recognized. Two new histological variants, type D (simulating
an aggressive epidermotropic cytotoxic lymphoma) and type E (angioinvasive
type) has been described recently. We describe a 27‑year‑old man presented
with a history of asymptomatic erythematous papules on both upper and lower
limbs noted since 10 years of age. There were no systemic symptoms. Biopsy
revealed an atypical dermal lymphoid infiltrate with epidermotropism, and the
immunohistochemical markers showed a diffuse positivity for CD3, CD8, CD56,
T1A and granzyme B with the focal positivity of CD30. All other relevant tests
were normal. In this case report of a recently described delineated variant of
LyP we emphasize the indolent course of this entity although the histology would
suggest a more aggressive disease.
Description
Keywords
CD30 lymphomas, cutaneous lymphoma, lymphomatoid papulosis
Citation
Mani Venkatraman, George Renu, Vijayakumar Kavita, Nair Sheila. Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma. Indian Journal of Pathology & Microbiology. 2016 Jan-Mar 59(1): 81-83.