Functional protein C and anti-cardiolipin antibody in children with portal vein thrombosis.

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dc.contributor.authorYachha, S Ken_US
dc.contributor.authorAggarwal, Ren_US
dc.contributor.authorSharma, B Cen_US
dc.contributor.authorMisra, R Nen_US
dc.contributor.authorAggarwal, Aen_US
dc.contributor.authorNaik, S Ren_US
dc.date.accessioned2001-03-18en_US
dc.date.accessioned2009-05-29T02:25:54Z
dc.date.available2001-03-18en_US
dc.date.available2009-05-29T02:25:54Z
dc.date.issued2001-03-18en_US
dc.description.abstractBACKGROUND: Portal vein thrombosis (PVT) is a common cause of portal hypertension in children from developing countries. Deficiencies of proteins C and S and elevated anticardiolipin antibody (aCL) levels have been shown to predispose to venous thrombosis. We studied these factors in children with idiopathic PVT. METHODS: 19 children with PVT (mean [SD] age 5.7 [2.1] y; 15 boys) were studied; all had had variceal bleeding, and had PVT on ultrasonography. Functional protein C activity was measured using a clotting assay; if it was normal, a clotting assay for functional protein S activity was performed. IgG aCL levels were measured in all sera using an in-house standardized solid-phase ELISA. RESULTS: Protein C functional activity ranged from 4% to 109%. Eight children had activity below 70%, the lower cut-off of the normal range. Protein S assay, done in 10 of the 11 children with normal protein C activity levels, was normal (above the cut-off level of 65% of the normal range). IgG aCL levels were abnormally elevated (>mean + 2SD of 16 healthy control children) in nine children; of these, three had associated protein C deficiency. Thus, of the 19 children with idiopathic PVT, 14 had abnormality in one or more tests. CONCLUSION: A majority of children with PVT of unknown etiology have functional protein C deficiency or abnormally elevated levels of aCL antibodies.en_US
dc.description.affiliationDepartment of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. skyachha@sgpgi.ac.inen_US
dc.identifier.citationYachha SK, Aggarwal R, Sharma BC, Misra RN, Aggarwal A, Naik SR. Functional protein C and anti-cardiolipin antibody in children with portal vein thrombosis. Indian Journal of Gastroenterology. 2001 Mar-Apr; 20(2): 47-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/64133
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAntibodies, Anticardiolipin --metabolismen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension, Portal --etiologyen_US
dc.subject.meshImmunoglobulin G --metabolismen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshPortal Veinen_US
dc.subject.meshProtein C Deficiency --complicationsen_US
dc.subject.meshProtein S Deficiency --complicationsen_US
dc.subject.meshVenous Thrombosis --complicationsen_US
dc.titleFunctional protein C and anti-cardiolipin antibody in children with portal vein thrombosis.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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