Field performance of VAQTA (inactivated, purified hepatitis a vaccine) in Chinese children in Jiangsu.

Simple item page
dc.contributor.authorWang, Huaen_US
dc.contributor.authorChen, Xen_US
dc.contributor.authorChen, Zhixianen_US
dc.contributor.authorLu, Wen_US
dc.contributor.authorPoerschke, Gabrieleen_US
dc.contributor.authorEves, Karenen_US
dc.contributor.authorGress, Jacquelineen_US
dc.contributor.authorKuter, Barbaraen_US
dc.date.accessioned2009-05-27T16:01:32Z
dc.date.available2009-05-27T16:01:32Z
dc.date.issued2004-12-27en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractIn Jiangsu, 30% of children between the ages of 5 and 8 years test seropositive for hepatitis A. The safety, tolerability, and immunogenicity of a 2-dose regimen (0, 6 months) of VAQTA (0.5 ml of 25U) administered IM in 50 healthy children aged 5 to 8 years without prior serological screening was evaluated. Blood samples were collected prior to the first dose and after each additional dose of VAQTA to determine the initial anti-HAV serostatus and response rates to the vaccine. Twelve children (24%) were initially seropositive and 38 (76%) were initially seronegative. Four weeks after the primary dose of VAQTA, 34 of the 38 subjects (89.5%, 95% CI 75 to 97) were anti-HAV seropositive. The geometric mean titer was 33.1 mIU/ml (95% CI 22.4 to 49.0). After the booster dose at 6 months, all the subjects were seropositive (37/37), giving a seroconversion of 100% (95% CI: 90, 100). The geometric mean titer was 7585.8 mIU/ml (95% CI: 5623.4 to 10,471.3). Adverse experiences were generally mild and transient. Results of this study are consistent with results from a previous double-blind randomized trial of this vaccine and confirm that VAQTA is highly immunogenic, and generally well-tolerated.en_US
dc.description.affiliationJiangsu Center of Disease Control, Jiangsu, China.en_US
dc.identifier.citationWang H, Chen X, Chen Z, Lu W, Poerschke G, Eves K, Gress J, Kuter B. Field performance of VAQTA (inactivated, purified hepatitis a vaccine) in Chinese children in Jiangsu. The Southeast Asian Journal of Tropical Medicine and Public Health. 2004 Dec; 35(4): 949-53en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34236
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2004_35_4/30-3320.pdfen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis A --blooden_US
dc.subject.meshHepatitis A Vaccines --adverse effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.titleField performance of VAQTA (inactivated, purified hepatitis a vaccine) in Chinese children in Jiangsu.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
949.pdf
Size:
33.93 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Southeast Asian Journal of Tropical Medicine and Public Health