Evaluation of antibiotic sensitivity pattern in cases of enteric fever in north west Rajasthan.

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dc.contributor.authorSaharan, Gopien_US
dc.contributor.authorGupta, Anjlien_US
dc.contributor.authorGupta, B Ken_US
dc.contributor.authorSharma, B Pen_US
dc.contributor.authorKochar, D Ken_US
dc.contributor.authorPurohit, V Pen_US
dc.date.accessioned2008-08-04en_US
dc.date.accessioned2009-05-31T08:20:35Z
dc.date.available2008-08-04en_US
dc.date.available2009-05-31T08:20:35Z
dc.date.issued2008-08-04en_US
dc.description.abstractA total of 50 cases of blood culture proved enteric fever were studied for clinical response to the treatment and compared with in vivo antibiotic sensitivity pattern. Out of 50 Salmonella strains isolated, 37 were S typhi and 13 S paratyphi A. All S typhi isolates were sensitive in vitro to gentamicin and ceftriaxone while sensitivity to ciprofloxacin was 73%, ampicillin 29.7%, chloromphenicol 27%, tetracycline 27% and co-trimoxazole 13.5%. Multidrug resistance (Ampicillin, Chloramphenicol, Cotrimoxazale and Tetracycline) was observed in 62% isolates. All Sparatyphi A isolates were sensitive to all the antibiotics. Clinical response to the antibiotic therapy was as follows: Group I--Ampicillin + Gentamicin: 15 cases, clinical response (CR), 9.1% (S typhi) and 75% (S paratyphi A), mean day of defervescence 5.33 days. Group II--Ciprofloxacin: 29 cases, clinical response 47.6% (S typhi) and 75% (S paratyphi A), mean day of defervescence--5.22 days. Group--III Ceftriaxone: 30 cases, clinical response 100% in all, mean day of defervescence--4.93 days. Thus we observed highly significant discrepancy in antibiotic sensitivity pattern of the isolates and clinical response. Most importantly we observed significantly delayed clinical response to the ceftriaxone. This may be indicative of evolving resistance to ceftriaxone.en_US
dc.description.affiliationDepartment of Medicine and Microbiology, SP Medical College and AG of Hospitals, Bikaner 334003.en_US
dc.identifier.citationSaharan G, Gupta A, Gupta BK, Sharma BP, Kochar DK, Purohit VP. Evaluation of antibiotic sensitivity pattern in cases of enteric fever in north west Rajasthan. Journal of the Indian Medical Association. 2008 Aug; 106(8): 528-30, 532en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/97656
dc.language.isoengen_US
dc.source.urihttps://www.jimaonline.org.in/en_US
dc.subject.meshAdolescenten_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshCeftriaxone --therapeutic useen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCiprofloxacin --therapeutic useen_US
dc.subject.meshDrug Resistance, Multiple, Bacterialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrobial Sensitivity Tests --statistics & numerical dataen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTyphoid Fever --blooden_US
dc.subject.meshYoung Adulten_US
dc.titleEvaluation of antibiotic sensitivity pattern in cases of enteric fever in north west Rajasthan.en_US
dc.typeComparative Studyen_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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