Renal humoral modulation of skeletal muscle tone in mice: implications for 'the pulmonary-renal cascade'.

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dc.contributor.authorTyagi, Manoj Gen_US
dc.contributor.authorVelu, S Thirumalaien_US
dc.contributor.authorVikram, Gota Sen_US
dc.date.accessioned2005-10-04en_US
dc.date.accessioned2009-06-01T05:31:43Z
dc.date.available2005-10-04en_US
dc.date.available2009-06-01T05:31:43Z
dc.date.issued2005-10-04en_US
dc.description.abstractThe pulmonary-renal cascade may regulate the respiration and skeletal muscle contractility. To evaluate this working hypothetical model, we conducted experiments to ascertain the skeletal muscle tone of the Swiss mice (20-35 g). The animals were evaluated for their skeletal muscle tone via several techniques i.e. inclined plane test, grip strength test and swim test. Groups of mice (n=6) were pre-treated with mefenamic acid (60 mg/kg, i.p), carbenoxolone (100 mg/kg i.p) or vehicle only 15 minutes before the treatment with heparin (500 U/kg, i.v), urokinase (5500 U/kg, i.v) and erythropoietin (150 U/kg, i.v). Heparin potentiated the loss of skeletal muscle tone induced by mefenamic acid and carbenoxolone while urokinase & erythropoietin significantly enhanced the skeletal muscle tone as evaluated by all or one of the tests. Other groups of mice (n=6) were pretreated with mefenamic acid (1 mg i.c.v), carbenoxolone (160 microg i.c.v) or minoxidil (30 microg i.c.v) and the effects of heparin & urokinase and erythropoietin on skeletal muscle tone were evaluated. To study the effects of heparin and urokinase on nerve regeneration, two groups of mice underwent a sham and sciatic nerve crush procedure. The mice treated with urokinase recovered much faster as compared to those treated with heparin or saline. These experimental results suggest that gap junction blockers and potassium channel openers interact with heparin, urokinase and erythropoietin to control the skeletal muscle tone.en_US
dc.description.affiliationDepartment of Pharmacology, Christian Medical College, Vellore--632 002. tyagi243@yahoo.co.inen_US
dc.identifier.citationTyagi MG, Velu ST, Vikram GS. Renal humoral modulation of skeletal muscle tone in mice: implications for 'the pulmonary-renal cascade'. Indian Journal of Physiology and Pharmacology. 2005 Oct-Dec; 49(4): 403-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106682
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --pharmacologyen_US
dc.subject.meshAnti-Ulcer Agents --pharmacologyen_US
dc.subject.meshAnticoagulants --pharmacologyen_US
dc.subject.meshCarbenoxolone --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHand Strength --physiologyen_US
dc.subject.meshHeparin --pharmacologyen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshKidney --drug effectsen_US
dc.subject.meshLung --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMefenamic Acid --pharmacologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMinoxidil --pharmacologyen_US
dc.subject.meshMuscle Tonus --drug effectsen_US
dc.subject.meshMuscle, Skeletal --drug effectsen_US
dc.subject.meshNerve Crushen_US
dc.subject.meshPlasminogen Activators --pharmacologyen_US
dc.subject.meshSciatic Nerve --physiologyen_US
dc.subject.meshSignal Transduction --drug effectsen_US
dc.subject.meshSwimming --physiologyen_US
dc.subject.meshUrokinase-Type Plasminogen Activator --pharmacologyen_US
dc.subject.meshVasodilator Agents --pharmacologyen_US
dc.titleRenal humoral modulation of skeletal muscle tone in mice: implications for 'the pulmonary-renal cascade'.en_US
dc.typeJournal Articleen_US
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