Benign versus malignant compression fracture: a diagnostic accuracy of magnetic resonance imaging.

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dc.contributor.authorPongpornsup, Sopaen_US
dc.contributor.authorWajanawichakorn, Phromphiangen_US
dc.contributor.authorDanchaivijitr, Nasudaen_US
dc.date.accessioned2009-05-27T21:52:03Z
dc.date.available2009-05-27T21:52:03Z
dc.date.issued2009-01-06en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To evaluate the accuracy, sensitivity, and specificity of various Magnetic Resonance Imaging (MRI) features in differentiating malignant from benign compression fracture of the spine. MATERIAL AND METHOD: Retrospective review of MRI spine of patients with vertebral compression fracture identified from the hospital database between June 2004 and February 2006 by two radiologists blinded to the clinical data. Various MRI features were evaluated for sensitivity, specificity, positive predictive value, and negative predictive value. An additional combination of two, three, four, and five MRI features that had statistically significant (P value less than 0.005) were also calculated for sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). RESULTS: Fifty-eight spinal MRI were included from 35 patients with metastatic vertebral compression fractures and 23 patients with benign vertebral compression fractures. MR imaging features suggestive of malignant vertebral compression fracture were convex posterior border of the vertebral body, involvement of the pedicle or posterior element, epidural mass, paraspinal mass, and destruction of bony cortex. Among these, involvement of pedicle or posterior element was the most reliable finding (sensitivity 91.4% and specificity 82.6%) for diagnosis of malignant vertebral compression fracture. A combination of two or more MRI features gave very high specificity and PPV. CONCLUSION: Certain MR imaging characteristics can reliably distinguish malignant from benign compression fracture of the spine. Combination of several MRI features strongly affirmed the diagnosis of malignant compression fracture, especially in a patient where tissue biopsy is not justified.en_US
dc.description.affiliationDepartment of Radiology, Siriraj Hospital Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationPongpornsup S, Wajanawichakorn P, Danchaivijitr N. Benign versus malignant compression fracture: a diagnostic accuracy of magnetic resonance imaging. Journal of the Medical Association of Thailand. 2009 Jan; 92(1): 64-72en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45541
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFemaleen_US
dc.subject.meshFractures, Compression --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshReproducibility of Resultsen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSpinal Fractures --diagnosisen_US
dc.subject.meshSpinal Neoplasms --complicationsen_US
dc.titleBenign versus malignant compression fracture: a diagnostic accuracy of magnetic resonance imaging.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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