High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene.

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dc.contributor.authorPatkar, Sushma
dc.contributor.authorCharita, B H
dc.contributor.authorRamesh, C
dc.contributor.authorPadma, T
dc.date.accessioned2012-06-07T09:46:53Z
dc.date.available2012-06-07T09:46:53Z
dc.date.issued2009-05
dc.description.abstractIn this study 250 patients with essential hypertension were investigated in comparison to 218 normotensives for association with epidemiological parameters. Of these DNA samples from 176 patients and 168 controls were analyzed for intron 4 27bp repeat polymorphism of eNOS gene. The study revealed significantly high risk of essential hypertension for individuals who were obese, with a positive family history and with non-vegetarian food habits. Though the intron 4b/a polymorphism of eNOS gene did not reveal any association with essential hypertension in general, males with a/a genotype of the polymorphism did show significantly high risk for developing hypertension.en_US
dc.identifier.citationPatkar Sushma, Charita B H, Ramesh C, Padma T. High risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene. Indian Journal of Human Genetics. 2009 May; 15(2): 49-53.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/138870
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910948/en_US
dc.subjectEssential hypertensionen_US
dc.subjectendothelial NOS geneen_US
dc.subjectpolymorphismen_US
dc.subject.meshFamily
dc.subject.meshFemale
dc.subject.meshFood Preferences
dc.subject.meshGenetic Predisposition to Disease --genetics
dc.subject.meshGenotype
dc.subject.meshHumans
dc.subject.meshHypertension --diagnosis
dc.subject.meshHypertension --epidemiology
dc.subject.meshHypertension --etiology
dc.subject.meshIndia --epidemiology
dc.subject.meshIntrons --genetics
dc.subject.meshMale
dc.subject.meshNitric Oxide Synthase Type III --genetics
dc.subject.meshObesity
dc.subject.meshPolymorphism, Genetics
dc.subject.meshRisk
dc.titleHigh risk of essential hypertension in males with intron 4 VNTR polymorphism of eNOS gene.en_US
dc.typeArticleen_US
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