Pathogenic Menace of MDR Bacteria in Stool and Throat Swab Surveillance Cultures of Hematopoietic Stem Cell Recipients and Evaluation of Post-Transplant Bloodstream Infections: A Cross-Sectional Study from A Tertiary Care Teaching Hospital of Kolkata, India

Simple item page
dc.contributor.authorChoudhury, Ken_US
dc.contributor.authorDeb, Sen_US
dc.contributor.authorKundu, Sen_US
dc.contributor.authorDhar, Ben_US
dc.contributor.authorDolai, TKen_US
dc.contributor.authorDey, JBen_US
dc.contributor.authorBhattacharjee, SGen_US
dc.date.accessioned2025-08-13T09:54:24Z
dc.date.available2025-08-13T09:54:24Z
dc.date.issued2025-03
dc.description.abstractBackground Infections with multidrug-resistant organisms (MDRO) may pose a threat to hematopoietic stem cell transplant recipients. Pre-transplant surveillance culture of stool and throat swabs may guide antibiotic therapy in these groups of patients. We have conducted this study to determine the profile of organisms isolated from stool and throat swab cultures, their susceptibility pattern, and the presence of MDRO to detect post-transplant bloodstream infections in this tertiary care teaching hospital in Kolkata. Methods This cross-sectional study was conducted over a period of one year between 1st January to 31st December 2023. Pre-transplant surveillance culture of stool and throat swabs were performed on seventy patients from the Department of Hematology and processed in the Department of Microbiology using standard laboratory guidelines and their antibiotic susceptibility was done as per CLSI 2023 guidelines. The organisms were phenotypically screened for drug resistance and molecular confirmation was done for carbapenemases producers. Bloodstream infections in these recipients were detected by blood culture. Results There were 70 transplant recipients in whom stool surveillance culture yielded maximum incidence of Escherichia coli of which 32.8% were MDRO. Throat surveillance culture yielded Escherichia coli with 51.8% MDRO. blaNDM was the most common carbapenemases gene detected. Post-transplant the incidence of bloodstream infections detected by blood culture was seen in 32 recipients with Acinetobacter baumannii being the predominant Gram-negative isolate. Conclusion Colonization with MDRO in HSCT recipients before transplant is a potential threat. Performing stool and throat surveillance cultures before transplantation can inform empirical antibiotic strategies and tailored individualized antibiotic treatment.en_US
dc.identifier.affiliationsDepartment of Microbiology, Burdwan Medical College, Burdwan, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, NRS Medical College, Kolkata, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, NRS Medical College, Kolkata, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, NRS Medical College, Kolkata, Indiaen_US
dc.identifier.affiliationsDepartment of Hematology, NRS Medical College, Kolkata, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, NRS Medical College, Kolkata, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, NRS Medical College, Kolkata, Indiaen_US
dc.identifier.citationChoudhury K, Deb S, Kundu S, Dhar B, Dolai TK, Dey JB, Bhattacharjee SG. Pathogenic Menace of MDR Bacteria in Stool and Throat Swab Surveillance Cultures of Hematopoietic Stem Cell Recipients and Evaluation of Post-Transplant Bloodstream Infections: A Cross-Sectional Study from A Tertiary Care Teaching Hospital of Kolkata, India. National Journal of Medical Research . 2025 Mar; 15(1): 27-33en_US
dc.identifier.issn2249-4995
dc.identifier.issn2277-8810
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252800
dc.languageenen_US
dc.publisherMedsci Publicationsen_US
dc.relation.issuenumber1en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.55489/njmr.150120251035en_US
dc.subjectBone marrow cell transplantationen_US
dc.subjectStool surveillance cultureen_US
dc.subjectDrug Resistanceen_US
dc.subjectBacteremiaen_US
dc.titlePathogenic Menace of MDR Bacteria in Stool and Throat Swab Surveillance Cultures of Hematopoietic Stem Cell Recipients and Evaluation of Post-Transplant Bloodstream Infections: A Cross-Sectional Study from A Tertiary Care Teaching Hospital of Kolkata, Indiaen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
NJMR2052v15n1p27.pdf
Size:
581.67 KB
Format:
Adobe Portable Document Format
Download
Collections
National Journal of Medical Research