Effect of intracerebroventricular methotrexate on brain amines.

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dc.contributor.authorMadhyastha, Sen_US
dc.contributor.authorSomayaji, S Nen_US
dc.contributor.authorRao, M Sen_US
dc.contributor.authorNalini, Ken_US
dc.contributor.authorBairy, K Len_US
dc.date.accessioned2005-10-04en_US
dc.date.accessioned2009-06-01T07:45:48Z
dc.date.available2005-10-04en_US
dc.date.available2009-06-01T07:45:48Z
dc.date.issued2005-10-04en_US
dc.description.abstractIntrathecal methotrexate in children with leukemia is known to cause seizures, dementia, leukoencephalopathy and cognitive dysfunction. To investigate the role of brain amines in cognitive dysfunction, male Wistar rats were given multiple intracerebroventricular injections of methotrexate. Our earlier studies in this regard revealed disruption of brain monoamines in hippocampus with severe cytotoxic effect on CA4 hippocampal neurons. Further extending this study, the levels of brain monoamines in frontal cortex, hypothalamus and brainstem were estimated by HPLC method and histopathological study of the frontal cortex. The concentration of all three-brain amine (norepinephrine, dopamine and serotonin) levels was reduced in 2 mg/kg dose of methotrexate in frontal cortex and brain stem. Hypothalamus did not show any significant change in brain monoamine levels. No structural changes in the frontal cortex neurons were observed. Disruption of brain monoamines has been proposed as a cause of brain dysfunction from this chemotherapy. The outcome of the study may have therapeutic implications in the management of childhood lymphoblastic leukemia.en_US
dc.description.affiliationDepartments of Anatomy, Kasturba Medical College, Manipal--576 119.en_US
dc.identifier.citationMadhyastha S, Somayaji SN, Rao MS, Nalini K, Bairy KL. Effect of intracerebroventricular methotrexate on brain amines. Indian Journal of Physiology and Pharmacology. 2005 Oct-Dec; 49(4): 427-35en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108403
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimetabolites --administration & dosageen_US
dc.subject.meshBiogenic Amines --metabolismen_US
dc.subject.meshBrain Chemistry --drug effectsen_US
dc.subject.meshDopamine --metabolismen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshMethotrexate --administration & dosageen_US
dc.subject.meshNorepinephrine --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSerotonin --metabolismen_US
dc.titleEffect of intracerebroventricular methotrexate on brain amines.en_US
dc.typeJournal Articleen_US
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