Disposition kinetics of infusion quinine in (Adult) Myanmar falciparum malaria patients
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1989-06-01
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To study the pharmacokinetics of infusion quinine in Myanmar patients, 14 adults with falciparum malaria (half of them were highly parasitised i.e more than 5
of rbc parasitised with malaria parasites) were infused with Quinine dihydrochloried 15 mg/kg body weight initially, followed by 7.5 mg/kg 8 hourly for 2 doses. This was followed by oral administration of Quinine sulphate 7.5 mg/kg for 7 days. Plasma concentrations of quinine until 6 hours after the initial loading dose were analysed for pharmacokinetic parameters.
of rbc parasitised with malaria parasites) were infused with Quinine dihydrochloried 15 mg/kg body weight initially, followed by 7.5 mg/kg 8 hourly for 2 doses. This was followed by oral administration of Quinine sulphate 7.5 mg/kg for 7 days. Plasma concentrations of quinine until 6 hours after the initial loading dose were analysed for pharmacokinetic parameters.
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Cho Cho Myint, Tin Shwe, Pe Than Myint. Disposition kinetics of infusion quinine in (Adult) Myanmar falciparum malaria patients. Myanmar Medical Journal. 1989; 34(2): 19-21