A clinico-pathological study of 29 cases of gliosarcoma with special reference to two unique variants.

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dc.contributor.authorSarkar, Cen_US
dc.contributor.authorSharma, M Cen_US
dc.contributor.authorSudha, Ken_US
dc.contributor.authorGaikwad, Sen_US
dc.contributor.authorVarma, Aen_US
dc.date.accessioned1997-09-05en_US
dc.date.accessioned2009-05-27T07:13:51Z
dc.date.available1997-09-05en_US
dc.date.available2009-05-27T07:13:51Z
dc.date.issued1997-09-05en_US
dc.description.abstractIn the present series, the clinical and pathological features of 29 patients of gliosarcoma diagnosed over a 12 yr period (1984-1995) are reviewed. Gliosarcomas constituted 0.48 per cent of all intracranial tumours and 4.9 per cent of all cases of glioblastoma multiforme. Most patients (68.6%) with these tumours were above 40 yr of age. However, an interesting observation in the present series was that 10.3 per cent of patients (3/29) were below 14 yr of age, the youngest being 9 months. A male preponderance was noted and the temporal lobe was involved in 55 per cent patients. Histologically, in 25 of the 29 tumours, the sarcomatous component had the appearance of fibrosarcoma. Tumours from 4 patients were unique in that one showed rhabdomyoblastic differentiation in the mesenchymal areas as confirmed by immunohistochemical stains and electron microscopy (gliomyosarcoma). In three others, the neoplastic spindle cell component was closely associated with discrete areas of osteogenic sarcoma. Follow up in 12 patients (including the 4 patients with unique variants) revealed poor outcome similar to glioblastomas. All of them died within 1 month to 1.5 yr following surgery and postoperative radiotherapy. This study possibly represents the most comprehensive and largest series of gliosarcomas being reported from India.en_US
dc.description.affiliationDepartment of Pathology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSarkar C, Sharma MC, Sudha K, Gaikwad S, Varma A. A clinico-pathological study of 29 cases of gliosarcoma with special reference to two unique variants. Indian Journal of Medical Research. 1997 Sep; 106(): 229-35en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19844
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBrain Neoplasms --pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshGliosarcoma --pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetrospective Studiesen_US
dc.titleA clinico-pathological study of 29 cases of gliosarcoma with special reference to two unique variants.en_US
dc.typeJournal Articleen_US
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