Antitumor activities of new iso(thio)cyanates and their nitrogen and sulphur heterocyclic phosphorus derivatives

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dc.contributor.authorMansoura, A. Abd-El-Maksouden_US
dc.contributor.authorAida, I. El-Makawyen_US
dc.contributor.authorAbdel-Aziem, Sekena H.en_US
dc.contributor.authorMaigali, Soher S.en_US
dc.contributor.authorEl-Hussieny, Marwaen_US
dc.contributor.authorMansour, Shaimaa T.en_US
dc.contributor.authorSoliman, Fouad M.en_US
dc.date.accessioned2020-10-16T08:55:51Z
dc.date.available2020-10-16T08:55:51Z
dc.date.issued2019-02
dc.description.abstractThe cytotoxic activity of Iso(thio)cyanate derivatives and some new organophosphorus compounds were determined,using MTT assay against human hepatocellular carcinoma (HepG2) and adenocarcinoma breast (MCF-7) incomparison with the reference drug 5-flurouracil. All the selected products have been tested and showed concentrationdependent increase in the growth inhibition percentage against HepG2 and MCF-7. Where, the thietane derivativesrevealed anticancer activity with IC50 (20, 8.9 µg/ml) against HepG2 and (20, 10.3 µg/ml) against MCF-7; while,thiazinane compounds showed IC50 (12.7, 32.5 µg/ml) against HepG2 and (20 and 20 µg/ml) against MCF7. The newly synthesized azetidines showed anticancer activity with IC50 (13.5 and 32.5 µg/ml) against HepG2and IC50 (10 and 25.9 µg/ml) against MCF-7 cancer. Moreover, azetidinedione compound exhibited more potentactivity than the azetidinone with both types of cancer cell lines. In addition, the cytotoxic activity of the iso(thio)cyanates, and malonamic acid methyl ester compound were also investigated. 4-Methoxyphenyl isothiocyanate andmethylisothiocyanate, with IC50 (25.9, 12.3 and 40, 20 µg/ml), respectively, against HepG2 and MCF-7 cancer cells.1, 2-Dichloro-4-isocyanato-benzene was similar in potency to the known anticancer drug 5-flurouracil with IC50 (5.3µg/ml) versus 5 µg/ml for 5-flurouracil against MCF-7. While, malonamic acid methyl ester compound had no effecton both types of cancer cell lines.en_US
dc.identifier.affiliationsOrganometallic and Organometalloid Chemistry Department, National Research Centre, 33 El Behouth st., Dokki P.O. 12622, Giza, Egypten_US
dc.identifier.affiliationsCell Biology Department, National Research Centre, 33 El Behouth st., Dokki P.O. 12622, Giza, Egypten_US
dc.identifier.affiliationsCell Biology Department, National Research Centre, 33 El Behouth st., Dokki P.O. 12622, Giza, Egypten_US
dc.identifier.affiliationsOrganometallic and Organometalloid Chemistry Department, National Research Centre, 33 El Behouth st., Dokki P.O. 12622, Giza, Egypten_US
dc.identifier.affiliationsOrganometallic and Organometalloid Chemistry Department, National Research Centre, 33 El Behouth st., Dokki P.O. 12622, Giza, Egypten_US
dc.identifier.affiliationsOrganometallic and Organometalloid Chemistry Department, National Research Centre, 33 El Behouth st., Dokki P.O. 12622, Giza, Egypten_US
dc.identifier.affiliationsOrganometallic and Organometalloid Chemistry Department, National Research Centre, 33 El Behouth st., Dokki P.O. 12622, Giza, Egypten_US
dc.identifier.citationMansoura A. Abd-El-Maksoud, Aida I. El-Makawy, Abdel-Aziem Sekena H., Maigali Soher S., El-Hussieny Marwa, Mansour Shaimaa T., Soliman Fouad M.. Antitumor activities of new iso(thio)cyanates and their nitrogen and sulphur heterocyclic phosphorus derivatives. Journal of Applied Pharmaceutical Science. 2019 Feb; 2019 Feb: 001-011en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210507
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber2en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2019.90201en_US
dc.subjectHuman HepG2en_US
dc.subjectMCF-7 cancer cellsen_US
dc.subjectcytotoxic activityen_US
dc.subject5-flurouracilen_US
dc.subjectiso(thio)cyanatesen_US
dc.subjectorganophosphorus compoundsen_US
dc.titleAntitumor activities of new iso(thio)cyanates and their nitrogen and sulphur heterocyclic phosphorus derivativesen_US
dc.typeJournal Articleen_US
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